摘要
免疫球蛋白A血管炎(IgAV),也称为过敏性紫癜,是儿童血管炎最常见的形式。IgAV的发病机制在很大程度上仍是未知的。该病以IgA1免疫沉积、补体因子和中性粒细胞浸润为特征,并伴有血管炎症。部分患者症状无需干预即可缓解,但部分患者会出现肾小球肾炎,称为免疫球蛋白A血管炎伴肾炎(IgAVN),其特征类似于IgA肾病(IgAN),包括血尿、蛋白尿和IgA在肾小球沉积,最终,这可能导致终末期肾病。
Immunoglobulin A vasculitis(IgAV), also referred to as Henoch-Sch9nlein purpura, is the most common form of childhood vasculitis. The pathogenesis of IgAV is still unknown. The disease is characterized by IgA1 immune deposits, complement factors and neutrophil infiltration, which is accompanied with vascular inflammation.Symptoms can resolve without intervention, but some patients develop glomerulonephritis with features similar to IgA nephropathy that include hematuria, proteinuria and IgA deposition in the glomerulus. Ultimately, IgVAN can lead to end-stage renal disease.
作者
周金洁
ZHOU Jinjie(Department of Dermatology,Maternal and Child Health Hospital of Hubei Province,Wuhan 430070,China)
出处
《皮肤科学通报》
2022年第6期547-551,共5页
Dermatology Bulletin
关键词
IgA血管炎
过敏性紫癜
病因
发病机制
Immunoglobulin A vasculitis(IgAV)
Henoch-Scho9nlein purpura(HSP)
Etiology
Pathogenesis
