摘要
目的探讨脑蛋白水解物治疗新生儿缺氧缺血性脑病缺氧缺血性脑病(HIE)的临床效果。方法选取2017年6月至2018年6月中国康复研究中心北京博爱医院收治的60例新生儿HIE患儿作为研究对象,根据患儿实际用药类型分为神经节苷脂组(n=30,神经节苷脂治疗)和脑蛋白组(n=30,脑蛋白水解物治疗),比较两组患儿临床疗效、病情恢复进展、炎症介质、神经修复状况、远期预后状况。结果脑蛋白组患儿治疗有效率明显高于神经节苷脂组,差异有统计学意义(P<0.05)。脑蛋白组患儿治疗后的意识、原始反射、肌张力恢复时间均短于神经节苷脂组,差异有统计学意义(P<0.05)。脑蛋白组患儿治疗14 d后血清超敏C反应蛋白(hs-CRP)、白细胞介素-18(IL-18)水平均低于神经节苷脂组,新生儿行为神经测定量表(NBNA)评分高于神经节苷脂组,差异有统计学意义(P<0.05)。随访6个月后,脑蛋白组患儿的运动发育指数(PDI)和智力发育指数(MDI)评分均高于神经节苷脂组,差异有统计学意义(P<0.05)。结论采用脑蛋白水解物治疗新生儿HIE患儿疗效良好,可有效控制炎症反应,还能改善患儿的行为神经恢复及预后效果。
Objective To investigate the clinical effects of cerebral protein hydrolysate therapy on neonatal hypoxic ischemic encephalopathy(HIE).Methods From June 2017 to June 2018,a total of 60 neonates with HIE admitted to Beijing Boai Hospital of China Rehabilitation Research Center were selected as the research objects.According to the actual medication types of the child patients,they were divided into ganglioside group(n=30,ganglioside treatment)and brain protein group(n=30,brain protein hydrolysate treatment).The clinical efficacy,recovery progress,inflammatory mediators,neurorepair and long-term prognosis of the 2 groups were compared.Results The effective rate of brain protein group was significantly higher than that of ganglioside group.The difference was statistically significant(P<0.05).The recovery time of consciousness,primitive reflex and muscle tone recovery time in brain protein group was shorter than that in ganglioside group.The difference was statistically significant(P<0.05).After 14 days of treatment,the levels of hs CRP and IL-18 in the brain protein group were lower than those in the ganglioside group,and the scores of NBNA were higher than those in the ganglioside group(P<0.05).After 6 months follow-up,the motor development index(PDI)and intellectual development index(MDI)scores of the children in the brain protein group were higher than those in the ganglioside group(P<0.05).Conclusion Brain protein hydrolysate is in treating neonatal HIE.It can effectively control inflammatory reaction and improve the recovery of behavioral nerve and prognosis of children.
作者
王建军
WANG Jian-Jun(Department of Neurosurgery,Beijing Boai Hospital,China Rehabilitation Research Center,Beijing 100068,China)
出处
《中国药物经济学》
2020年第2期51-54,共4页
China Journal of Pharmaceutical Economics
关键词
新生儿
缺氧缺血性脑病
脑蛋白水解物
行为神经
智力发育
运动发育
Newborn
Hypoxic ischemic encephalopathy
Brain protein hydrolysate
Behavioral nerve
Intellectual development
Sports development
