摘要
阿尔茨海默病(Alzheimer’s disease,AD)是一种机制复杂、发病原因不明的原发性中枢退行性疾病,目前尚缺乏有效防治方法。肠道微生物可通过肠道和大脑间的双向信息交流影响AD的发展。近年国内外的研究表明,微生物-肠-脑轴在AD调控方面具有重要的作用,许多物质可通过该途径影响AD的发展进程。综述微生物-肠-脑轴与AD间的关系,以及益生菌和中药通过微生物-肠-脑轴对AD的调节,以期为AD的机制研究和治疗提供参考。
Alzheimer’s disease(AD)is a primary central degenerative disease with complicated mechanism and unknown etiology.At present,there is no effective prevention and treatment method for AD.Gut microbiota can influence AD development through a bidirectional information exchange between the gut and brain.Recent studies have shown that the microbial-gut-brain axis plays an important role in the regulation of AD,and many substances can influence the development of AD through this pathway.In this paper,the interaction between microbiota-gut-brain axis and AD as well as the regulation of AD by probiotics and traditional Chinese medicine through microbiota-gut-brain axis were reviewed in order to provide the reference for the study of the mechanism and treatment of AD.
作者
厉颖
徐敏
龙宇
尹子丽
高鹏飞
LI Ying;XU Min;LONG Yu;YIN Zili;GAO Pengfei(Yunnan Provincial Key Laboratory of Entomological Biopharmaceutical R&D,Dali University,Dali 671000,Yunnan,China;Yunnan Provincial Academy of Science and Technology,Kunming 650031,Yunnan,China;The Second Hospital of Nanhua University,Hengyang 421001,Hunan,China;College of Chinese Ethnic Medicine,Yunnan University of Chinese medicine,Kunming 650500,Yunnan,China)
出处
《中华中医药学刊》
CAS
北大核心
2022年第5期152-157,共6页
Chinese Archives of Traditional Chinese Medicine
基金
国家自然科学基金(81260676,81960712)
中国国家留学基金(201708535007)
云南省教育厅科学研究基金重点项目(2013Z154)
云南省地方本科高校(部分)基础研究联合专项(2018FH001-097)
云南省2019年中药饮片产业发展专项资金(2019-YG-067)
