摘要
[目的]观察贲门癌肝转移治疗中微球栓塞联合动脉灌注化疗的疗效及对患者远期预后的影响。[方法]回顾性分析100例贲门癌肝转移患者的基线资料,根据治疗方式的不同将其分为A组(53例,微球栓塞+动脉灌注化疗)和B组(47例,动脉灌注化疗)。比较2组基线资料;比较2组治疗前后吞咽功能、临床疗效、不良反应发生情况;采用Kaplan-Meier法分析2组术后3年生存情况,并行Log-rank检验。[结果]2组性别、年龄、BMI、肿瘤直径、组织分化程度、浸润深度、淋巴结转移、肝转移类型及肝转移直径等基线资料比较,均差异无统计学意义(P>0.05);2组治疗后吞咽功能Ⅲ~Ⅴ级构成比均降低(P<0.05),A组低于B组(P<0.05);A组临床总有效率高于B组(P<0.05);A组疼痛、恶心发生率高于B组(P<0.05);A组1、2、3年生存率均高于B组(P<0.05)。生存曲线显示A组中位生存期长于B组(P<0.05)。[结论]贲门癌肝转移治疗中微球栓塞联合动脉灌注化疗可改善患者的吞咽困难,疗效确切,提高了远期生存率,但会增加不良反应的发生。
[Objective]To observe the efficacy of microsphere embolization combined with intra-arterial infusion chemotherapy in the treatment of gastric cardia metastasis and its effect on long-term prognosis.[Methods]The baseline data of 100 patients with liver metastases from cardiac cancer were retrospectively analyzed.Patients were divided into group A(53 cases,microsphere embolization+arterial infusion chemotherapy)and group B(47 cases,arterial infusion chemotherapy)according to different treatment methods.The baseline data of the two groups were compared.The swallowing function of the two groups was compared before and after treatment.The clinical efficacy and adverse reactions of the two groups were compared.The Kaplan-Meier method was used to analyze the survival of the two groups after 3 years,and the Log-rank test was performed.[Results]There were no significant differences in baseline data between gender,age,BMI,tumor diameter,tissue differentiation degree,depth of invasion,lymph node metastasis,liver metastasis type and liver metastasis diameter of two groups(P>0.05).The composition ratio of gradeⅢ-Ⅴwere both decreased of two groups(P<0.05),which of the group A was lower than that of group B(P<0.05).The total effective rate of group A was significantly higher than that of group B(P<0.05).The incidence of pain and nausea of group A was higher than that of group B(P<0.05).The survival rate was higher than that of group B(P<0.05).The 1-year,2-year and 3-year survival rates of group A were higher than those of group B(P<0.05).Survival curves showed that the median survival of group A was longer than that of group B(P<0.05).[Conclusion]Microsphere embolization combined with intra-arterial infusion chemotherapy in the treatment of gastric cardia cancer can alleviate dysphagia in patients with curative effect and improve long-term survival rate,but it will lead to increased pain and nausea.
作者
亢春生
李彪
张菲菲
吴涛
KANG Chun-sheng;LI Biao;ZHANG Fei-fei;WU Tao(Department of Interventional Therapy,Lu'an Hospital,Peking Medical College,Peking University,Changzhi 046000,China)
出处
《中国中西医结合消化杂志》
CAS
2020年第3期210-214,共5页
Chinese Journal of Integrated Traditional and Western Medicine on Digestion
基金
国家自然科学基金(No:81501567).
关键词
微球栓塞
动脉灌注化疗
贲门癌肝转移
远期预后
microsphere embolization
arterial infusion chemotherapy
cardia cancer liver metastasis
long-term prognosis
