摘要
目的:观察加味二仙汤对阳虚质骨质疏松症患者体质状态、腰背部及关节处疼痛、肢体活动状况、骨密度、骨代谢生化指标的影响,对可能的作用机制进行探讨。方法:将符合要求的100例阳虚质骨质疏松症患者随机分为治疗组及对照组,各50例。对照组给予基础抗骨质疏松治疗,治疗组用加味二仙汤联合基础治疗,为期6周。记录分析患者治疗前后腰背部与关节处疼痛评分、阳虚症状积分及肢体活动状况(short physical performance battery,SPPB)评分;测定患者治疗前后血清钙(calcium,Ca),血磷(phosphorus,P),腰椎1-4(L1-4),股骨颈骨密度(bone mineral density,BMD),骨钙素(osteocalcin,BGP)及I型前胶原氨基端肽(type 1 procollagen amino terminal peptide,P1NP)水平的变化情况。结果:治疗前两组的腰背及关节处疼痛评分,阳虚症状积分,肢体功能活动评分,L1-4及股骨颈骨密度,Ca,P,BGP及P1NP比较无统计学差异;治疗6周后,治疗组肢体活动状况评分,L1-4及股骨颈骨密度,血清Ca,P水平高于对照组(P<0.05);治疗组腰背部及关节处疼痛评分,阳虚症状积分,BGP及P1NP水平低于对照组(P<0.05)。结论:加味二仙汤可以显著减轻阳虚质骨质疏松症患者腰背部及关节处疼痛,增强肢体功能活动状况,改善患者体质状态,提高骨密度,降低骨转换,对阳虚质骨质疏松有良好的治疗与改善症状的作用。
Objective:To observe the effect of modified Erxian decoction on the physical condition,pain in the lower back and joints,limb activity,bone density,bone metabolism and biochemical indexes in patients with osteoporosis caused by Yang deficiency,in order to explore the possible mechanism.Method:Totally 100 cases of osteoporosis with Yang deficiency were randomly divided into treatment group and control group,with 50 cases in each group.The control group was treated with basic anti-osteoporosis therapy,and the treatment group was give modified Erxian decoction combined with basic therapy for 6 weeks.Short physical performance battery(SPPB)scores of low back and joint pain and Yang deficiency symptom score before and after treatment were recorded and analyzed.before and after treatment,the changes of blood serum calcium(Ca),phosphorus(P),L1-4,femoral neck bone mineral density(BMD),osteocalcin(BGP)and type I collagen peptide amino end level(P1NP)were measured.Result:The scores of lumbar back and joint pain,Yang deficiency symptom score,limb function and activity,lumbar spine 1-4(L1-4),femoral neck BMD,Ca,P,BGP and P1NP between two groups before treatment had no statistically significant difference.After 6 weeks of treatment,limb activity score,L1-4,femoral neck BMD,serum Ca and P levels in treatment group were significantly higher than those in control group(P<0.05).The scores of the pain in the lower back and joints,Yang deficiency symptom score,BGP and P1NP in treatment group were significantly lower than those in control group(P<0.05).Conclusion:Modified Erxian decoction can significantly alleviate the pain in the lower back and joints of patients with osteoporosis caused by Yang deficiency,enhance the limb function and activity status,improve the physical condition and bone density of patients,reduce bone conversion,with a good effect in treating and alleviating symptoms of osteoporosis caused by Yang deficiency.
作者
陈世洲
毛国庆
孙玉明
曹鲁梅
秦龙秀
姚瑶
葛健峰
CHEN Shi-zhou;MAO Guo-qing;SUN Yu-ming;CAO Lu-mei;QIN Long-xiu;YAO Yao;GE Jian-feng(Affiliated Hospital of Nanjing University of Chinese Medicine,Nanjing 210029,China)
出处
《中国实验方剂学杂志》
CAS
CSCD
北大核心
2020年第7期104-108,共5页
Chinese Journal of Experimental Traditional Medical Formulae
基金
江苏省研究生培养创新工程项目(SJCX19_0405)
第四批全国中医优秀人才研修项目(J20184832009)
江苏省中医传统运动康复技术项目(K2017ykf08).
关键词
加味二仙汤
骨质疏松症
阳虚质
骨密度
骨代谢
modified Erxian decoction
osteoporosis
Yang deficiency
bone mineral density
bone metabolism
