摘要
中枢神经系统疾病常由自由基水平引起,自由基的异常增加,将导致系统的氧化应激,从而引起相应的中枢神经系统类疾病或者异常。由于血脑屏障的存在,常规治疗方式无法发挥作用,而miRNA在中枢神经系统疾病中存在独特的优势,一方面可越过血脑屏障,另一方面靶细胞能够摄取miRNA,从而直接作用于靶基因,故miRNA在阿尔茨海默症、帕金森综合征等疾病的发生、发展、诊断及治疗中都发挥了重要作用。国内外许多研究均发现miRNA的异常是导致该类神经系统疾病发生的重要原因。基于此,本文综述近年来文献所报道的相应miRNA与中枢神经性疾病之间的关系。
Central nervous system diseases may be often caused by free radicals level,whose abnormal increase may lead to oxidative stress in system,resulting in corresponding central nervous system diseases or abnormalities.However,due to existence of blood-brain barrier,routine treatments can not function.The miRNA has unique advantages in central nervous system disease,which can cross blood-brain barrier,on the other hand,target cell can take up miRNA and act on target gene directly.Therefore,miRNA plays an important role in the occurrence,development,diagnosis and treatment of Alzheimer’s disease,Parkinson’s syndrome and other diseases.Many studies at home and abroad have found that abnormality of miRNA is an important cause of neurological disease.Based on this,the article reviews the relationship between corresponding miRNAs and central nervous diseases,which was reported in literature in recent years.
作者
杨永杰
王宇蝶
符庆臻
李祎莹
YANG Yong-jie;WANG Yu-die;FU Qing-zhen;LI Yi-ying(Hainan Medical College,Haikou,Hainan,571199)
出处
《智慧健康》
2020年第33期31-32,共2页
Smart Healthcare
基金
海南医学院2016年培育基金(项目编号:HY2016-1)
2020年海南省科协青年科技英才创新计划项目(项目编号:QCXM202023)
海南医学院创新创业训练计划项目(项目编号:HYCX2016017)
海南医学院创新创业训练计划项目(项目编号:201711810016)
