摘要
目的探讨分泌型脑膜瘤(SM)的临床病理学特点。方法回顾性分析11例SM患者的临床病理特点并复习相关文献。结果SM患者以女性居多(7/11),部位以大脑凸面居多(45.5%)。肿瘤细胞胞质内可见特征性嗜酸性分泌小体,PAS染色均呈阳性。肿瘤细胞均表达Vimentin、CEA、PR、AE1/AE3、SSTR 2,绝大部分表达EMA,Ki-67指数<1%~4%。KLF4突变6例,TRAF7突变1例。9例术后随访5~55个月,均未见复发或转移。结论SM具有独特的临床病理形态学特征,预后较好。
Objective To investigate the clinicopathological features of secretory meningioma(SM).Methods The clinical and pathological features were observed and related literatures were reviewed.Results In the study,the majority of SM patients were women(7/11),with the lesions most commonly occurring on the convex surface of the brain(45.5%).Under the microscope,the characteristic eosinophilic secretions were found in all the cases,PAS staining was positive.The tumor cells were positive for Vimentin,CEA,PR,AE1/AE3(6/6),SSTR 2(4/4);EMA(10/11),S-100(1/10),the expression rate of Ki-67 value-added index was<1%-4%.All the 11 cases were diagnosed as SM,WHO grade 1.6 had KLF4(K409Q)mutation,and 1 had TRAF7(G536S)mutation.9 patients were followed up for 5-55 months,and no recurrence or metastasis was found.Conclusion SM presents with unique pathological morphological features,and has a good prognosis.
作者
马进
申耀元
刘林华
邵明昱
MA Jin;SHEN Yao-yuan;LIU Lin-hua;SHAO Ming-yu(Deparment of Pathology,People’s Hosiptal of Xinjiang Uygur Autonomous Region,Urumqi 830001,China)
出处
《诊断病理学杂志》
2023年第9期880-883,共4页
Chinese Journal of Diagnostic Pathology
关键词
脑膜瘤
分泌型
嗜酸性分泌小体
Meningioma
Secretory type
Eosinophilic secretion
