摘要
目的探讨多奈哌齐联合尼莫地平对阿尔茨海默症患者临床症状的改善效果。方法选取无锡市第六人民医院爱心护理院2014年6月至2019年6月收治的阿尔茨海默症患者60例作为研究对象,随机分为两组。对照组30例患者单纯采用多奈哌齐治疗,观察组30例患者采用多奈哌齐联合尼莫地平治疗,疗程为6个月。比较分析两组精神症状、认知、日常生活能力改善情况。结果治疗前两组简易智能精神状态评价量表(MMSE)和神经精神科问卷(NPI)评分比较,差异无统计学意义(P>0.05);治疗后,观察组MMSE评分显著高于对照组,NPI评分低于对照组(P<0.05)。治疗前两组阿尔茨海默病认知评价量表(ADAS-cog)和日常生活能力量表(ADL)评分比较无明显差异(P>0.05);治疗后,观察组上述评分低于对照组(P<0.05)。观察组不良反应发生率为10.00%,与对照组的6.67%比较,差异无统计学意义(P>0.05)。结论采用多奈哌齐联合尼莫地平治疗阿尔茨海默症能够促进患者精神行为症状、改善认知功能,提高日常生活能力,且安全性高。
Objective To investigate the effect of donepezil combined with nimodipine on the improvement of clinical symptoms in patients with Alzheimer’s disease.Methods A total of 60 patients with Alzheimer’s disease who were treated in Love Nursing Hospital of Wuxi Sixth People’s Hospital from June 2014 to June 2019 were selected as the research objects,and they were randomly divided into two groups by the lottery method.Thirty patients in the control group were treated with donepezil alone,and 30 patients in the observation group were treated with donepezil combined with nimodipine.The course of treatment was 6 months,and the improvement of mental symptoms,cognition and daily living ability were compared and analyzed between the two groups.Results There were no significant difference in the scores of the Simple Intelligent Mental State Evaluation Scale(MMSE)and the Neuropsychiatric Questionnaire(NPI)between the two groups before treatment(P>0.05).After 6 months of treatmen,the MMSE score of the observation group was significantly higher than that of the control group;NPI score of the observation group was significantly lower than that of the control group(P<0.05).There were no significant difference in the scores of the Alzheimer’s Disease Cognitive Evaluation Scale(ADAS-cog)and the Ability of Daily Living Scale(ADL)between the two groups before treatment(P>0.05).After 6 months of treatment,ADAS-cog and ADL scores in the observation group were significantly lower than those of the control group(P<0.05).The incidence of adverse reactions in the observation group was 10.00%,which was not statistically significant compared with6.67%of the control group(P>0.05).Conclusion The clinical treatment of Alzheimer’s disease using donepezil combined with nimodipine can promote patients’mental and behavioral symptoms,improve cognitive function,improve their daily living ability,and have high safety.
作者
王菁
WANG Jing(Love Nursing Hospital of Wuxi Sixth People’s Hospital,Wuxi 214092,Jiangsu,China)
出处
《慢性病学杂志》
2020年第2期177-179,共3页
Chronic Pathematology Journal
