摘要
目的探讨精液不液化患者精子浓度、前向活动精子、正常形态率与精子DNA碎片的相关性。方法选取2020年8月—2022年8月本院收治的100例精液不液化患者作为实验组,另选同期生育功能健康男性100例作为对照组。比较2组精子浓度、前向活动精子、正常形态率及精子DNA碎片指数(DFI)间差异,并采用Pearson相关性分析精子浓度、前向活动精子、正常形态率与精子DFI的相关性。结果实验组精子浓度、前向活动精子、正常形态率分别为(40.36±4.25)×10^(6)/L、(25.74±3.25)%、(7.89±1.12)%,低于对照组的(76.85±7.39)×10^(6)/L、(47.89±4.32)%、(22.41±2.89)%,精子DFI为(29.47±3.42)%,高于对照组的(14.25±1.36)%,差异有统计学意义(t=42.804、40.973、46.847、41.353,P均<0.001);Pearson相关分析显示,精子浓度、前向活动精子、正常形态率均与精子DFI呈负相关(r=-0.485、-0.437、-0.476,P均<0.001)。结论精液不液化患者精子浓度、前向活动精子及正常形态率偏低,精子DFI偏高,且精液常规参数与精子DFI呈负相关,可为临床评估男性生育力提供重要参考。
Objective To investigate the correlation between sperm concentration,forward motile sperm,normal morphological rate,and sperm DNA fragmentation in patients with non-liquefaction of semen.Methods A total of 100 patients with non-liquefaction semen admitted to our hospital from August 2020 to August 2022 were selected as an experimental group,and 100 men with healthy fertility function during the same period were selected as a control group.The differences between sperm concentration,forward motile sperm,normal morphological rate,and sperm DNA fragmentation index(DFI)between the two groups were compared,and the correlation among sperm concentration,forward motile sperm,normal morphological rate,and sperm DFI was analyzed by Pearson correlation.Results The sperm concentration,forward motile sperm,and normal morphological rates in the experimental group were(40.36±4.25)×10^(6)/L,(25.74±3.25)%,and(7.89±1.12%)%,respectively,which were lower than those in the control group:(76.85±7.39)×10^(6)/L,(47.89±4.32)%,(22.41±2.89%)%,and the sperm DFI in the experimental group was(29.47±3.42)%,higher than that in the control group:(14.25±1.36)%,and all the differences were statistically significant(t=42.804,40.973,46.847,41.353,all P<0.001).Pearson correlation analysis showed that sperm concentration,forward motile sperm,and normal morphological rate were negatively correlated with sperm DFI(r=-0.485,-0.437,-0.476,all P<0.001).Conclusion The patients with non-liquefaction of semen have low sperm concentration,forward motile sperm and normal morphological rate,high sperm DFI,and the conventional parameters of semen are negatively correlated with sperm DFI,which can provide an important reference for clinical evaluation of male fertility.
作者
黄燕兰
郭腾捷
HUANG Yanlan;GUO Tengjie(Department of Clinical Laboratory,Zhangzhou Hospital of Traditional Chinese Medicine,Zhangzhou 363000,Fujian,China)
出处
《中国校医》
2023年第12期925-927,共3页
Chinese Journal of School Doctor
关键词
精液不液化
精子浓度
前向活动精子
精子DNA碎片
相关性分析
Non-liquefaction semen
Sperm concentration
Forward motile sperm
Sperm DNA fragmentation
Correlation analysis
