摘要
非编码RNA中的环状RNA(circular RNA,circRNA)在三阴性乳腺癌的肿瘤发生及进展中起着突出的作用。全文总结与三阴性乳腺癌相关circRNA的生物学特点及调控机制与通路,探讨其在影响药敏及调控代谢重编程中的作用,以及作为治疗靶点及生物标志物的价值,为三阴性乳腺癌临床诊断与治疗提供参考依据。
Circular RNAs(circRNAs),a type of non-coding RNAs,play a prominent role in the tumorigenesis and progression of triple-negative breast cancer(TNBC).In this paper the biological characteristics,regulatory mechanisms and pathways of circRNAs associated with TNBC are summarized.The effects of circRNAs on drug sensitivity and metabolic reprogramming,and their value as therapeutic targets and biomarkers are discussed to provide reference for the clinical diagnosis and treatment of TNBC.
作者
黄馨仪
刘晓
HUANG Xin-yi;LIU Xiao(The Affiliated Wuxi People’s Hospital of Nanjing Medical University,Wuxi 214000,China)
出处
《肿瘤学杂志》
CAS
2023年第5期425-429,共5页
Journal of Chinese Oncology
关键词
环状RNA
三阴性乳腺癌
药敏
代谢重编程
治疗靶点
生物标志物
circular RNA
triple-negative breast cancer
drug sensitivity
metabolic reprogramming
therapeutic targets
biomarkers
