摘要
目的 探讨分析糖尿病肾病维持性血液透析患者认知功能、心理状况及生活质量相关性。方法 选取2019年4月-2021年3月在我院肾内科住院治疗58例维持性血液透析患者作为观察组,并选取同期在我院住院治疗的50例单纯2型糖尿病患者作为对照组,并选择同期在我院健康体检的50例健康志愿者作为健康对照组。采用简易精神状态检查(MMSE)调查三组受试者认知功能,采用抑郁自评量表(SDS)以及焦虑自评量表(SAS)分析对三组受试者心理状况,采用健康状况调查问卷(SF-36)对三组受试者生活质量进行调查,并分析MMSE评分与SDS、SAS及SF-36的相关性。结果 观察组患者MMSE评分明显低于对照组和健康对照组(P<0.05)。三组受试者SDS、SAS比较,差异具有统计学意义(P<0.05),观察组患者SDS、SAS评分显著高于对照组和健康对照组(P<0.05),且对照组患者SDS、SAS评分显著高于健康对照组(P<0.05)。三组受试者生活质量各维度评分具有显著差异(P<0.05),其中观察组患者SF-36生活质量各维度评分显著低于对照组和健康对照组(P<0.05),而对照组SF-36生活质量各维度评分均显著低于健康对照组(P<0.05)。对糖尿病维持性血液透析患者认知功能、心理状况及生活质量评分进行相关性分析,结果显示:糖尿病维持性血液透析患者MMSE评分与SDS、SAS评分呈显著负相关关系(P<0.05),而糖尿病维持性血液透析患者MMSE评分与SF-36生活质量各维度评分均呈显著正相关关系(P<0.05)。结论 糖尿病血液透析患者存在明显的认知功能降低、不良心理情绪严重以及生活质量差的特点,且患者认知功能与其心理状态及生活质量密切相关,值得临床关注。
Objective: To explore the correlation among cognitive function, psychological status and quality of life in diabetic nephropathy(DN) patients with maintenance hemodialysis. Methods: 58 maintenance hemodialysis patients who were hospitalized in our hospital from April 2019 to March 2021 were selected as the observation group, and 50 patients with pure type 2 diabetes who were hospitalized in our hospital at the same time were selected as the control group, and 50 healthy volunteers who were in our hospital for health examination at the same time were selected as the health control group. The simple mental state examination(MMSE) was used to investigate the cognitive function of the subjects in the three groups. The self-rating depression scale(SDS) and self-rating anxiety scale(SAS) were used to analyze the psychological status of the subjects in the three groups. The health status questionnaire(SF-36) was used to investigate and analyze the quality of life of the subjects in the three groups and the correlation between MMSE scores and SDS, SAS and SF-36 was also analyzed. Results: The scores of MMSE in observation group were significantly lower than those in control group and healthy control group(P<0.05). The differences of SDS and SAS scores among the three groups were statistically significant(P<0.05). The SDS and SAS scores in the observation group were significantly higher than those in the control group and healthy control group(P<0.05). The SDS and SAS scores of patients in the control group were significantly higher than those in the healthy control group(P<0.05). The scores of each dimension of QOL were significantly different among the three groups(P<0.05). The scores of each dimension of SF-36 QOL in the observation group were significantly lower than those in the control group and the healthy control group(P<0.05), while the scores of each dimension of SF-36 QOL in the control group were significantly lower than those in the healthy control group(P<0.05). Correlation analysis was performed on the cognitive function, psychological condition and quality of life scores of diabetic patients with maintenance hemodialysis. The results showed that MMSE scores of diabetic patients with maintenance hemodialysis had a significant negative correlation with SDS and SAS scores(P<0.05), while MMSE scores of diabetic patients with maintenance hemodialysis had a significant positive correlation with SF-36 scores of all dimensions of quality of life(P<0.05). Conclusion: Diabetic patients with hemodialysis have obvious characteristics of declined cognitive function, severe adverse psychological emotions and poor quality of life. Moreover, patients’ cognitive function is closely related to their psychological state and quality of life, which needs to be paid attention to in clinic.
作者
徐伟
XU Wei(Leping Tianhu Hospital,Leping Jiangxi 333300,China)
出处
《透析与人工器官》
2022年第4期82-86,共5页
Chinese Journal of Dialysis and Artificial Organs
关键词
糖尿病肾病
维持性血液透析
认知功能
心理状况
生活质量
diabetic nephropathy
maintenance hemodialysis
cognitive function
psychological status
quality of life
