摘要
目的观察中药四逆汤对脓毒性休克患者液体管理的临床疗效。方法将45例脓毒性休克患者随机分为中药组与对照组。监测两组患者在治疗后第0、2、4、6、12、24h的容量状态及容量反应性,包括血乳酸浓度、乳酸清除率、床旁超声监测下腔静脉变异度(ΔIVC)、肺部B线;两组患者待早期复苏达标后,监测达标时间、补液量、液体净平衡量。结果中药组早期复苏达标时间更短,补液量更少,液体净平衡量更低,两组差异有统计学意义(P<0.05)。结论四逆汤能够缩短脓毒性休克患者早期复苏达标时间,降低补液量,从而可能改善患者预后。
Objective To study the clinical efficacy of Sini Decoction on fluid management in patients with septic shock.Methods Forty-five patients with septic shock were divided into conventional treatment group and Sini decoction group.The volume status and volume responsiveness of patients in the two groups at 0,2,4,6,12,and 24 hours of the treatment,including blood lactate concentration,lactate clearance rate,inferior vena cava variability(ΔIVC),and changes of lung B line were monitored.After the patients in the two groups reached the standard in early resuscitation,the time of reaching the standard,the amount of fluid replacement,and the net fluid balance were monitored.Results In the Chinese medicine group,the time to reach the standard of early resuscitation was shorter,the amount of rehydration was less,and the net balance of liquid was lower.The difference between the two groups was statistically significant(P<0.05).Conclusions Sini Decoction can shorten the time of early resuscitation in patients with septic shock and reduce the amount of fluid infusion,which may improve the prognosis of patients.
作者
孙月雯
徐沁
张沥元
吴海荣
Sun Yuewen;Xu Qin;Zhang Liyuan;Wu Hairong(Wuxi Traditional Chinese Medicine Hospital,Wuxi,China)
基金
无锡市中医药管理局(项目编号:ZYKJ202109)
无锡市卫健委中青年拔尖人才项目(项目编号:HB2020065)
无锡市卫健委适宜技术推广项目(项目编号:T202040)
关键词
四逆汤
脓毒性休克
液体净平衡
床旁超声
下腔静脉变异度
Sini Decoction
Septic shock
Net liquid balance
Bedside ultrasound
Inferior vena cava variability
