摘要
组织常驻记忆T细胞(tissue-resident memory T cells,TRM)是最近发现的记忆T淋巴细胞亚群。这类细胞不参与血液循环,当病原体被消除后仍长期存在于组织中,在病原再次侵入时即刻发挥保护作用。但是,TRM异常激活可能参与了自身免疫和炎症性疾病的发病机制。近年来,这类细胞在银屑病、白癜风、黑素瘤、变应性接触性皮炎等皮肤病中均被描述过。该文就TRM在皮肤病中的研究进展做一综述。
TRM cells are a newly identified subset of memory T cells,which do not recirculate in the blood.TRM cells remain for extended periods of time after pathogens were eliminated and provide immediate protection upon re-infection with the same antigen.However,increasing evidence suggests that aberrant activation of these cells might contribute to the pathogenesis of autoimmune and inflammatory diseases.In recent years,these cells have been described in vitiligo,psoriasis,melanoma and other diseases.This article reviews the research progress of TRM in dermatosis.
作者
李佳颖
朱威
LI Jia-ying;ZHU Wei(Department of Dermatology and Venereology,Xuanwu Hospital of Capital Medical University,Beijing 100053,China)
出处
《实用皮肤病学杂志》
2022年第6期347-350,共4页
Journal of Practical Dermatology
