摘要
微生物的次级代谢产物在医药领域一直发挥着重要的作用。然而,已知化合物频繁地在微生物单一培养中被发现,已成为天然产物化学中亟待解决的问题。将两种或多种微生物放在一起共同培养的方法,试图模仿微生物在微生物群落中共存的生态环境,通过微生物之间竞争或共生的关系来刺激或促进沉默生物合成途径的表达,从而产生新的化合物。本文综述了3种类型的微生物相互作用,包括细菌与细菌、真菌与真菌、真菌与细菌,从中发现的活性化合物,并对用于分析共培养产物的现代化技术进行了介绍。
Microbial secondary metabolites have always played an important role in drug discovery.But the known compounds are frequently found in the single culture of microorganisms,which has become an urgent problem in natural product chemistry.A method of co-cultivating two or more microorganisms,is trying to mimic the ecological environment in which microorganisms coexist in the natural microbial community.The competition or symbiotic relationship between microorganisms can stimulate or promote the expression of silent gene cluster to produce the novel compounds.In this article,three types of microbial interaction were reviewed,including bacteria and bacteria,fungi and fungi,and fungi and bacteria,as well as the active compounds produced from them.And modern techniques for analyzing co-culture products were also introduced.
作者
武文惠
WU Wen-hui(School of Pharmaceutical Science and Technology,Tianjin University,Tianjin 300072,China)
出处
《当代化工》
CAS
2020年第12期2804-2807,2831,共5页
Contemporary Chemical Industry
基金
国家自然科学基金外国青年学者研究基金(项目编号:81850410550)
关键词
共培养
真菌
细菌
次级代谢产物
Co-culture
Fungi
Bacteria
Secondary metabolites
