摘要
肠道微生物菌落在出生时已开始建立,婴幼儿期是微生物菌落和宿主建立关系的重要时期,也是婴幼儿大脑发育的关键阶段。在生命的前2~3年,婴儿的肠道菌群迅速繁殖,逐渐变得多样化和丰富,随着对肠道微生态研究的不断深入发现生命早期肠道微生态的异常建立与婴幼儿罹患孤独症谱系障碍(ASD)的关系密切,而目前对ASD的诊断一般在3岁以后,诊断后治疗困难,故对ASD相关的危险因素进行早期筛查与预防就显得尤为重要。笔者主要回顾生命早期肠道微生物的生理、病理状态下的主导菌群及ASD相关微生物-肠-脑轴方面的研究进展,提出对可能患有ASD的高危人群在肠道菌群稳定之前进行早期干预,使其肠道菌群恢复至正常生理状态,达到降低ASD发生率的可能,希望能够为临床早期筛查及预防ASD提供参考。
Intestinal microbial communities have been established at birth.Infancy is an important period for establishing relationships between microbial communities and hosts,and also a critical stage in infant brain development.In the first two to three years of life,the infantile intestinal flora rapidly multiplies and gradually becomes diversified and enriched.With the continuous deepening of intestinal microecology research,it is found that the abnormal establishment of intestinal microecology in early life is closely related to ASD in infants and young children.The current diagnosis of ASD is generally after 3 years of age,and it is difficult to treat after diagnosis.Therefore,it is particularly important to filter and prevent ASD-related risk factors.This paper mainly reviews the research progress of the dominant flora in the physiological and pathological conditions of the gut microbes in early life and the ASD-related microbes-intestinal-brain axis.It is proposed that early intervention should be carried out for the high-risk groups with possible ASD in the early stage before the intestinal flora is stable,so as to restore the intestinal flora to normal physiological state and reduce the incidence of ASD,provide reference for early clinical screening and prevention of ASD.
作者
何勇
冯爱民
张卉
夏璐
HE Yong;FENG Aimin;ZHANG Hui(Department of Pediatrics,Affiliated Hospital of Shaanxi University of Traditional Chinese Medicine,Xianyang 712000;不详)
出处
《陕西医学杂志》
CAS
2020年第3期381-385,共5页
Shaanxi Medical Journal
基金
陕西中医药大学中西医结合防治脑发育障碍性疾病创新团队项目(2019-YL07).
