摘要
目的探讨儿童慢性咳嗽的吸入性变应原皮试结果。方法选择2014-02-01-2017-02-01郑州大学第三附属医院儿内科门诊收治的1054例慢性咳嗽患儿为研究对象,均进行皮肤点刺试验,应用点刺液为北京协和医院变应原生产研制中心研制的变应原点刺液,共26种。生理盐水作为阴性对照,组胺作为阳性对照。分析患儿的变应原皮试结果。结果1054例患儿中,874例患儿对≥1种变应原呈阳性反应,总阳性率为82.92%,180例患儿全阴性。5类不同变应原中,螨类阳性率为59.10%,花粉类阳性率为38.04%,蚊虫类阳性率为37.76%,霉菌类阳性率为25.61%,动物毛皮阳性率为20.01%,不同类别吸入性过敏原阳性率比较,差异有统计学意义,χ2=413.18,P<0.05。阳性率排名前5位的依次为粉尘螨、户尘螨、蟑螂、油菜花和柳树,阳性率最高的5种吸入性变应原强度比较,差异有统计学意义,χ2=243.88,P<0.05。其中螨类(粉尘螨、户尘螨)强阳性率(+++及+++以上阳性率)高于其他类别变应原。行皮肤点刺试验的1054例患儿均未见严重不良反应。结论以尘螨为主的多源性过敏是河南郑州地区儿童慢性咳嗽的主要原因,尘螨阳性和阳性强度均居首位。对慢性咳嗽患儿开展皮肤点刺试验,有助于明确变应原,帮助查找儿童慢性咳嗽的病因。
Objective Explored the results of inhaled allergen skin test for children with chronic cough.Methods A total of 1054 children with chronic cough in the Outpatient Department of Pediatrics of the Third Affiliated Hospital of Zhengzhou University from February 1,2014 to February 1,2017 were selected for skin prick test.The applied prick liquid was allergen prick liquid developed by Allergen Production and Research Center of Peking Union Medical College Hospital.There were 26 kinds.Physiological saline was used as a negative control and histamine was used as a positive control.Analyzed the results of allergen skin tests in children.Results 874 of 1054 children were positive for at least one allergen.The total positive rate was 82.92%,and 180 cases were all negative.Among the five different allergens,the positive rate of mites was 59.10%,the positive rate of pollen was 38.04%,the positive rate of mosquitoes was 37.76%,the positive rate of molds was 25.61%,and the positive rate of animal fur was 20.01%.Compared with the positive rate of inhaled allergens,the difference was statistically significant,χ2=413.18,P<0.05.The top 5 positive rates were dust mites,house dust mites,cockroaches,rape flowers and willows.The comparison of the five kinds of inhaled allergens with the highest positive rate showed that there was statistically significant,χ2=243.88,P<0.05.Among them,the strong positive rate of mites(dust mites,house dust mites)(+++and above positive rates)was higher than other types of allergens.There were no serious adverse reactions in 1054 children who underwent skin prick test.Conclusions Multisource allergies,mainly dust mites,are the main cause of chronic coughing in children in Zhengzhou,Henan.The positive and positive intensity of dust mites rank first.Carrying out skin prick tests on children with chronic cough can help identify allergens and help find the cause of children’s chronic cough.
作者
蔡春玲
郑月红
CAI Chun-ling;ZHENG Yue-hong(Department of Pediatrics,the Third Affiliated Hospital of Zhengzhou University,Zhengzhou450052,China)
出处
《社区医学杂志》
CAS
2021年第10期595-597,共3页
Journal Of Community Medicine
