摘要
槐耳(Trametes robiniophila Murr.)是一味中草药,在临床上对各种肿瘤的治疗展现出了良好的效果。本文通过总结近年来槐耳抗癌的最新研究进展,介绍了槐耳的主要活性成分,包括槐耳粗体物、多糖类物质以及其他活性物质;阐述了槐耳在肺癌、肝癌、乳腺癌、消化道癌等恶性肿瘤中的研究及其作用机制,包括抑制增殖和转移、阻滞细胞周期、诱导凋亡和自噬、抗肿瘤内血管生成、增强肿瘤免疫原性微环境等;介绍了槐耳在临床应用以及联合用药过程中亟待解决的问题;旨在为槐耳的推广应用于临床提供参考。
Huaier(Trametes robinophila Murr.)is a kind of Chinese herbal medicine,which has shown good effects in the clinical treatment of various tumors.By summarizing the latest research progress in anticancer of Huaier in recent years,this review describes the main active components of Huaier,including its crusade substances,polysaccharides and other active substances;research on Huaier in lung cancer,liver cancer,breast cancer,digestive tract cancers and other malignant tumors and anti-tumor mechanism,including inhibition of proliferation and metastasis,blockade of cell cycle,induction of apoptosis and autophagy,anti-angiogenesis in tumors,enhancement of tumor immunogenic microenvironment,etc;and problems that need to be solved urgently in the clinical application and combined drug use of Huaier.This paper aims to provide a reference for the large-scale clinical application of Huaier in the future by discussing the above three aspects.
作者
乔旭鹏
罗程
丁煦审
叶科祺
安朗
托雷
姜东伯
杨琨
QIAO Xupeng;LUO Cheng;DING Xushen;YE Keqi;AN Lang;TUO Lei;JIANG Dongbo;YANG Kun(College of Medical Technology,Shaanxi University of Chinese Medicine,Xianyang 712046,China;Department of Immunology,Basic Medicine School,Air-Force Medical University,Xi′an 710032,China;Brigade of Cadet,Basic Medicine School,Air-Force Medical University,Xi′an 710032,China)
出处
《生命的化学》
CAS
2023年第1期124-129,共6页
Chemistry of Life
基金
国家自然科学基金项目(82073154,82203510)
关键词
槐耳
恶性肿瘤
信号通路
分子机制
Huaier
malignancy
signaling pathway
molecular mechanism
