摘要
目的研究单味中药及复方治疗盆腔炎性疾病后遗症的作用机制。方法对Pubmed、Web of Science、中国知网和万方等数据库进行检索,寻找建库至2023年3月以来关于中药治疗SPID及作用机制的相关文献,并对文献进行归纳整理。结果共纳入文献428篇,从纳入文献中筛选出从调节细胞因子和炎症介质分泌水平、促进炎症细胞凋亡、抑制脂质过氧化、抑制组织纤维化、改善血液循环、调节代谢途径和细胞信号转导、调节免疫能力等方面报道单味中药及复方治疗盆腔炎性疾病的作用机制。结论为中药治疗盆腔炎性疾病后遗症作用机制进行深入研究,并对其新药研发提供参考。
Objective To study the mechanism of single Chinese medicine and compound in the treatment for sequelae of pelvic inflammatory disease.Methods We searched Pubmed,Web of Science,CNKI,Wanfang and other databases,to find out relevant literature on the treatment of SPID and their mechanism of herbal medicine since the etablishment of the database to March 2023,and summarized the literatures.Results A total of 428 literatures were included,from the included literature,we screened reports on the mechanism of of single Chinese medicine and compound in the treatment of pelvic inflammatory disease,including regulating the secretion level of cytokines and inflammatory mediators,promoting the apoptosis of inflammatory cells,inhibiting lipid peroxidation,inhibiting tissue fiber,improving blood circulation,regulating metabolic pathways and cell signal transduction,and regulating immunity etc.Conclusion To conduct in-depth research on the mechanism of action of traditional Chinese medicine in the treatment of sequelae of pelvic inflammatory disease and to provide reference for the development of new drugs of SPID.
作者
程力
唐潇冉
何成瑶
袁琴
赵超
胡成凤
CHENG Li;TANG Xiaoran;HE Chengyao;YUAN Qin;ZHAO Chao;HU Chengfeng(The Second Clinical Medical College of Guizhou University of Traditional Chinese Medicine,Guiyang 550001,China;the Research Center for Quality Control of Natural Medicine,Guizhou Normal University,Guiyang 550001,China)
出处
《世界科学技术-中医药现代化》
CSCD
北大核心
2024年第4期988-1000,共13页
Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology
基金
第四届国医大师传承工作室建设项目(国中医药办人教函[2022]245号):何成瑶国医大师传承工作室建设项目,负责人:刘正奇
贵州省科技计划项目(黔科合支撑[2021]一般020):腕踝针对子宫腺肌病患者高强度聚焦超声消融术后镇痛的临床疗效评价研究,负责人:袁琴
关键词
盆腔炎性疾病后遗症
中药
作用机制
Sequelae of pelvic inflammatory disease(SPID)
Traditional Chinese medicine(TCM)
Mechanism of action
