摘要
目的研究共煎煮对不同比例配伍(1∶3、1∶2、1∶1、2∶1、3∶1)的苍术-白术药对挥发油成分的影响。方法水蒸气蒸馏法提取苍术、白术单煎和共煎煮挥发油,气相色谱-质谱联用技术(GC-MS)分析各挥发油的组成。结果苍术-白术药对各比例配伍共煎组挥发油得率均高于分别单煎,共煎煮后绝大多数成分在混合挥发油中的实测相对含量与理论计算含量有明显差异。共煎煮能促进苍术挥发油主成分茅苍术醇的提取,与大剂量白术配伍(1∶2和1∶3)还能同时促进β-桉叶醇的溶出;同时,共煎煮能抑制白术挥发油主成分苍术酮、大根香叶烯B和巴伦西亚橘烯的提取。结论苍术、白术配伍共煎煮能提高挥发油提取率,并且改变挥发油类成分的组成含量,其中苍术活性成分溶出增加,而白术活性成分溶出减少,这可能会导致共煎煮后药对药理活性的改变。
Objective To study the changes of volatile oil of Atractylodis Rhizoma(AR)and Atractylodis macrocephalae Rhizoma(AMR)before and after co-decocting in different proportions(1∶3,1∶2,1∶1,2∶1,3∶1).Methods The volatile oil was extracted by steam distillation and analyzed by gas chromatography-mass spectrometry(GC-MS).Results After co-decocting,the yield of volatile in each group was higher than in single decocting.The relative contents of most components in the mixed volatile oil after co-decocting were significantly different from the theoretical calculation.Co-decocting could promote the extraction of hinesol,which is the main component of the essential oil of AR,and the compatibility with large doses of AMR(1∶2 and 1∶3)could also promote the dissolution ofβ-eudesmol.At the same time,the extraction of atractylon,germacrene B and valencene was inhibited by co-decocting,which were the main constituents of the volatile oil of AMR.Conclusion Co-decocting of AR and AMR could improve the extraction rate and change the chemical composition of volatile oil.After co-decocting,the dissolution of active components of AR increased,while the dissolution of active components of AMR decreased.It may lead to the change of pharmacological activity.
作者
宋宝宏
唐雪梅
马旻新
王伟
蒋媛媛
敖慧
陈璐
Song Baohong;Tang Xuemei;Ma Minxin;Wang Wei;Jiang Yuanyuan;Ao Hui;Chen Lu(State Key Laboratory of Southwestern Chinese Medicine Resources,School of Pharmacy,Chengdu University of Traditional Chinese Medicine,Chengdu 611137,China;Chengdu Institute of Food Inspection,Chengdu 610045,China;Sichuan Institute for Drug Control,Chengdu 611731,China;Chengdu University of Traditional Chinese Medicine,Innovative Institute of Chinese Medicine and Pharmacy,Chengdu 611137,China)
出处
《世界科学技术-中医药现代化》
CSCD
北大核心
2023年第11期3585-3591,共7页
Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology
基金
国家中医药管理局全国名老中医药专家传承工作室建设项目(国中医药人教函[2019]41号):万德光全国名老中医药专家传承工作室,负责人:裴瑾
四川省中医药管理局四川省中医药重点学科建设项目([2020]84号):药用植物学重点学科建设,负责人:裴瑾
关键词
苍术
白术
药对
共煎煮
挥发油
气相色谱-质谱联用技术
Atractylodis Rhizoma
Atractylodis macrocephalae Rhizoma
Couplet medicines
Co-decocting
Volatile oil
GC-MS
