摘要
目的:探讨脉络宁口服液联合利拉鲁肽对2型糖尿病周围神经病变氧化应激及肌电图指标的影响。方法:选取2022年7月至2023年7月我院收治的112例2型糖尿病周围神经病患者,根据不同治疗方案将其分为对照组和研究组,各56例,对照组接受利拉鲁肽治疗,研究组接受脉络宁口服液联合利拉鲁肽治疗,比较两组临床疗效、中医症候积分、多伦多临床评分系统(TCSS)评分、炎症因子、氧化应激指标、肌电图指标、不良反应及随访期间的生活质量。结果:研究组治疗总有效率(82.14%)较对照组(67.86%)更高(P<0.05);治疗后,研究组中医证候积分、TCSS评分低于对照组(P<0.05);治疗后,研究组TNF-α、IL-6、CRP均低于对照组(P<0.05);治疗后,研究组MDA低于对照组,SOD高于对照组(P<0.05);治疗后,研究组腓总神经、正中神经的MCV、SCV均高于对照组(P<0.05);两组不良反应发生率(3.57%vs5.36%)比较无统计学差异(P>0.05);疗程结束后及随访后各阶段,研究组生活质量BP评分均高于对照组(P<0.05)。结论:脉络宁口服液联合利拉鲁肽可提高2型糖尿病周围神经病患者临床疗效,改善其临床症状,减轻其炎症反应及氧化应激反应,提高其神经传导速度,且安全性较高。
Objective:To investigate the effects of Mailuoning oral liquid combined with Liraglutide on oxidative stress and EMG indexes in type 2 diabetic peripheral neuropathy.Methods:A total of 112 patients with type 2 diabetic peripheral neuropathy admitted to our hospital from July 2022 to July 2023 were selected,According to different treatment plans,the patients were divided into control group and study group,56 cases each,The control group received liraglutide treatment,the study group received Mailuoning oral liquid combined with liraglutide treatment.Clinical efficacy,TCM syndrome score,Toronto Clinical Scoring System(TCSS)score,inflammatory factors,oxidative stress index,EMG index,adverse reactions and quality of life during follow-up were compared between the two groups.Results:The total effective rate of the study group(82.14%)was higher than that of the control group(67.86%)(P<0.05).After treatment,TCM syndrome scores and TCSS scores in the study group were lower than those in the control group(P<0.05).After treatment,TNF-α,IL-6 and CRP in the study group were lower than those in the control group(P<0.05).After treatment,MDA in the study group was lower than that in the control group,and SOD was higher than that in the control group(P<0.05).After treatment,MCV and SCV of common peroneal nerve and median nerve in study group were higher than those in control group(P<0.05).There was no significant difference in the incidence of adverse reactions(3.57%vs5.36%)between the two groups(P>0.05).After treatment and follow-up,the BP score of the study group was higher than that of the control group(P<0.05).Conclusion:Mailuoning oral liquid combined with Liraglutide can improve the clinical efficacy,improve the clinical symptoms,reduce the inflammatory reaction and oxidative stress reaction,and increase the nerve conduction speed in patients with type 2 diabetes peripheral neuropathy,and has high safety.
作者
马立云
李兰
闫丽兰
张琼之
董秀芳
董欣
刘杰
Ma Li-Yun;LI Lan;YAN Li-Lan;ZHANG Qiong-Zhi;DONG XiU-Fang;DONG Xin;LIU Jie(The First Affiliated Hospital of Xingtai Medical College(The First Hospital of Xingtai),Xingtai 054000,China;Neiqiu Hospital of Traditional Chinese Medicine,Xingtai 054200,China;Xingtai Hospital of Traditional Chinese Medicine(formerly Xingtai Fifth Hospital),Xingtai 054000,China)
出处
《生命科学仪器》
2023年第6期30-34,共5页
Life Science Instruments
基金
邢台市重点研发计划自筹项目(2023ZC111)
关键词
脉络宁口服液
利拉鲁肽
2型糖尿病周围神经病变
炎症因子
氧化应激
肌电图
Mailuoning oral liquid
Liraglutide
Type 2 diabetic peripheral neuropathy
Inflammatory factors
Oxidative stress
electromyogram
