摘要
目的:观察连花清瘟颗粒联合阿奇霉素治疗儿童支原体肺炎(MPP)临床疗效及对支原体-IgM(MP-IgM)转阴率、支气管镜下黏膜修复率及血清降钙素原(PCT)水平的影响。方法:将200例MPP患儿随机分为联合组和对照组各100例。联合组给予连花清瘟颗粒联合阿奇霉素治疗,对照组给予阿奇霉素治疗。2组均治疗2周。比较2组临床疗效、支气管镜下黏膜修复率、MP-IgM转阴率、症状改善时间、住院时间、肺功能指标[呼吸峰流速值(PEF)、第1秒用力呼气容积(FEV_(1))、FEV_(1)/用力肺活量(FVC)]、血清PCT水平及不良反应发生率。结果:联合组总有效率为93.00%,对照组为81.00%,2组比较,差异有统计学意义(P<0.05)。治疗后,联合组支气管镜下黏膜修复率、MP-IgM转阴率分别为72.00%、82.00%,对照组分别为53.00%、70.00%,2组比较,差异均有统计学意义(P<0.05)。联合组肺复张、肺部啰音消失、喘息缓解、咳痰缓解、咳嗽缓解、体温恢复及住院时间均短于对照组,差异有统计学意义(P<0.05)。治疗后,2组PEF、FEV_(1)、FEV_(1)/FVC水平均较治疗前升高(P<0.05),且联合组上述各项指标均高于对照组(P<0.05)。治疗后,2组血清PCT水平均较治疗前降低(P<0.05),且联合组PCT水平低于对照组(P<0.05)。联合组不良反应发生率为7.00%,对照组为9.00%,2组比较,差异无统计学意义(P>0.05)。结论:连花清瘟颗粒联合阿奇霉素治疗儿童MPP可有效改善患儿临床症状,提高支气管镜下黏膜修复率、MP-IgM转阴率及肺功能,减轻炎症反应,安全有效。
Objective:To observe the clinical effect of the therapy of Lianhua Qingwen Granules combined with Azithromycin on mycoplasma pneumoniae pneumonia(MPP)and its effect on the negative conversion rate of mycoplasma pneumoniae-IgM(MP-IgM),repair rate of mucosa under bronchoscope and level of serum procalcitonin(PCT).Methods:A total of 200 MPP children were randomly divided into the combination group and the control group,with 100 cases in each group.The combination group was given Lianhua Qingwei Granules combined with Azithromycin for treatment,and the control group was treated with Azithromycin.Both groups were treated for 2 weeks.The clinical effects,repair rate of mucosa under bronchoscope,MP-IgM negative conversion rate,improvement time,hospitalization time,indexes of lung function,including peak expiration flow(PEF),forced expiratory volume in one second(FEV_(1)),and ration of FEV_(1) and forced vital capacity(FVC),serum PCT levels and incidence of adverse reactions were compared between the two groups.Results:The total effective rate was 93.00%in the combination group and 81%in the control group,the difference being significant(P<0.05).After treatment,the repair rate of mucosa under bronchoscope and MP-IgM negative conversion rate were respectively 72.00%and 82.00%in the combination group,and 53.00%and 70.00%in the control group,differences being significant(P<0.05).The hospitalization time,lung recruitment time,disappearance time of lung wheezes,response time of panting,expectoration and cough,and recovery time of body temperature in the combination group were shorter than those in the control group,the difference being significant(P<0.05).After treatment,the levels of PEF,FEV_(1) and FEV_(1)/FVC in both groups were increased when compared with those before treatment(P<0.05),and the above 3 levels in the combination group were higher than those in the control group(P<0.05).After treatment,the serum PCT levels in both groups were decreased when compared with those before treatment(P<0.05),and the PCT level in the combination group was higher than that in the control group(P<0.05).The incidence of adverse reactions was 7.00%in the combination group and 9.00%in the control group,there being no significant difference(P>0.05).Conclusion:The therapy of Lianhua Qingwen Granules combined with Azithromycin can effectively improve the clinical symptoms of MPP children,increase the repair rate of mucosa under bronchoscope,MP-IgM negative conversion rate and lung function,and reduce inflammatory reaction with good safety and curative effects.
作者
赵月华
王伟伟
刘姗
ZHAO Yuehua;WANG Weiwei;LIU Shan(Department of Pediatrics,The First Affiliated Hospital of Henan University of Science and Technology,Luoyang Henan 471000,China)
出处
《新中医》
CAS
2023年第20期100-104,共5页
New Chinese Medicine
关键词
支原体肺炎
儿童
连花清瘟颗粒
阿奇霉素
MP-IgM转阴率
支气管镜下黏膜修复率
Mycoplasma pneumoniae pneumonia
Children
Lianhua Qingwen Granules
Azithromycin
MP-IgM negative conversion rate
Repair rate of mucosa under bronchoscope
