摘要
目的分析孕产妇宫内感染的血清指标表达水平及病原菌的分布情况。方法选取2017年10月-2021年7月如皋市人民医院收治的孕产妇感染者120例作为研究对象,并将其设为感染组,另选取同期正常的孕产妇80名设为对照组。比较两组孕产妇血清C-反应蛋白(CRP)、降钙素原(PCT)、白细胞介素-6(IL-6)的水平;比较不同程度宫内感染孕产妇血清CRP、PCT、IL-6的水平;分析孕产妇阴道炎和宫内感染主要病原菌的情况。结果感染组孕产妇的血清CRP、PCT、IL-6水平均明显高于对照组,差异有统计学意义(t=18.328、18.289、59.851,P均<0.05)。经宫内感染评估,其中轻度感染57例(47.50%),中度感染38例(31.67%),重度感染25例(20.83%);重度感染孕产妇的血清CRP、PCT、IL-6水平明显高于轻度感染(t=6.174、16.699、61.676,P均<0.05)和中度感染(t=2.909、6.523、12.102,P均<0.05),而中度感染亦明显高于轻度感染(t=2.856、11.357、53.098,P均<0.05),差异均有统计学意义。在120例孕产妇宫内感染中,共有92例(76.67%)曾患产前阴道炎,明显高于非阴道炎的28例(23.33%),差异有统计学意义(χ^(2)=68.267,P<0.05);滴虫性阴道炎与念珠菌阴道炎的感染率明显高于细菌性阴道炎(χ^(2)=25.325、9.391,P均<0.05)。在120例孕产妇宫内感染中,主要是由金黄色葡萄球菌、表皮葡萄球菌、粪大肠菌群等病原菌引起的宫内感染。结论孕产妇宫内感染的临产前血清CRP、PCT、IL-6水平均明显高于正常孕产妇,且其与宫内感染的严重程度相关,可共同作为孕产妇宫内感染的预测指标。阴道炎会增加孕产妇宫内感染的发生率,金黄色葡萄球菌在孕产妇宫内感染中占有较大比重。
Objective To discuss and analyze the expression level of serum indexes of pregnant women’s intrauterineinfection and the distribution of pathogenic bacteria.MethodsA total of 120 cases of pregnant women who were infected inour hospital from October 2017 to July 2021 were selected as the research object and set as the infection group.In addition,80 cases of normal pregnant women during the same period were selected as the control group.The levels of serum C-reactive protein(CRP),procalcitonin(PCT)and interleukin-6(IL-6)between the two groups of pregnant women werecompared.The serum CRP,PCT and IL-6 levels of pregnant women with different degrees of intrauterine infection werecompared;the main pathogenic bacteria of pregnant women with vaginitis and intrauterine infection were analyzed.ResultsThe Serum CRP,PCT and IL-6 levels in infected group were significantly higher than those in control group(t=18.328,18.289,59.851,all P<0.05).By intrauterine infection assessment,57 cases(47.50%)were mild infection,38cases(31.67%)were moderate infection,and 25 cases(20.83%)were severe infection.Serum CRP,PCT and IL-6 levelsof severely infected women were significantly higher than those of mild infection(t=6.174,16.699,61.676,all P<0.05)and moderate infection(t=2.909,6.523,12.102,all P<0.05).Serum CRP,PCT and IL-6 levels of moderate infection wassignificantly higher than those of mild infection(t=2.856,11.357,53.098,all P<0.05).Among 120 cases of intrauterineinfection,92 cases(76.67%)had suffered from prenatal vaginitis,significantly higher than 28 cases(23.33%)(χ^(2)=68.267,P<0.05).The infection rate of trichomonas vaginitis and candida vaginitis was significantly higher than that of bacterial vaginitis(χ^(2)=25.325,9.391,all P<0.05).Among the 120 cases of intrauterine infection,the main pathogens were Staphylococcus aureus,Staphylococcus epidermidis and fecal coliform bacteria.ConclusionsThe prenatal serum CRP,PCT and IL-6 levels of pregnant women with intrauterine infection were significantly higher than those of normal pregnant women.They were related to the severity of intrauterine infection and could be used as predictors of intrauterine infection in pregnant women;vaginitis would increase the incidence of intrauterine infections in pregnant women;Staphylococcus aureus was the main pathogen of intrauterine infections in pregnant women.
作者
杨志华
段丽娜
印琴琴
卜洁
YANG Zhi-hua;DUAN Li-na;YIN Qin-qin;BO Jie(Department of Obstetrics,Rugao People's Hospital,Rugao,Jiangsu 226500,China)
出处
《热带医学杂志》
CAS
2022年第11期1525-1528,共4页
Journal of Tropical Medicine
基金
南通市卫生和计划生育委员会科研课题(QB2020016)
