摘要
目的探讨氩等离子体凝固(APC)与联合冷冻对中央气道狭窄(CAO)合并肺部感染患者症状的改善及对降钙素原(PCT)、超敏C反应蛋白(hs-CRP)、白细胞计数(WBC)、中性粒细胞计数(NEUT)和肺功能的影响。方法选取2016年7月-2019年7月辽阳市中心医院收治的CAO合并肺部感染患者80例,随机分为APC组(n=40)和APC联合冷冻组(n=40)。APC组给予单纯APC治疗,APC联合冷冻组给予APC联合冷冻治疗,比较两组患者治疗前后气管内径、血氧饱和度、美国胸科协会(ATS)气促评分、肺功能指标[用力肺活量(FVC)和1秒用力呼气容积(FEV;)]及血清PCT、hs-CRP、WBC、NEUT水平变化,记录两组术后相关不良反应发生情况。结果与治疗前比较,治疗后两组患者气管内径均增大(P<0.05),但治疗后两组间差异无统计学意义(P>0.05)。与治疗前比较,治疗后两组血氧饱和度、FVC及FEV;均升高(P<0.05),且APC联合冷冻组均高于APC组(P<0.05),差异有统计学意义。与治疗前比较,治疗后两组ATS气促评分、血清PCT、hs-CRP、WBC、NEUT水平均显著降低(P<0.05),且APC联合冷冻组ATS气促评分、hs-CRP、NEUT水平均低于APC组(P<0.05),差异有统计学意义。APC联合冷冻组出血发生率、低氧血症发生率均显著低于APC组,差异有统计学意义(P<0.05)。结论APC与联合冷冻可显著缓解CAO合并肺部感染患者临床症状,有效降低其血清PCT、hs-CRP含量及WBC、NEUT水平,抑制机体炎症反应,恢复其肺功能,疗效优于APC单纯治疗,且具有良好的安全性。
Objective To explore the symptoms improvement and effect on procal citonin(PCT),hypersensitive C-reactive protein(hs-CRP)and white blood cell count(WBC),neutrophil counts(NEUT)and lung function of argon plasma coagulation(APC)combined with cyclocryotherapy for patients with central airway stenosis(CAO)combined with lung infection.Methods 80 patients with CAO combined with lung infection in our hospital from Apr 2016 to May 2019 were selected and divided into APC group and APC combined with cyclocryotherapy group according to random number table method,40 cases for each group,and treated with APC therapy alone and APC combined with cyclocryotherapy,respectively.The tracheal diameter,blood oxygen saturation,American Thoracic Society(ATS)shortness of breath score,lung function index and serum PCT,hs-CRP,WBC,NEUT indexes changes of patients in 2 groups were compared before and after treatment;the occurrence of postoperative related adverse reactions in 2 groups were recorded.Results Compared with before treatment,the tracheal diameter of patients in 2 groups increased after treatment(P<0.05),but which in 2 groups after treatment had no significant difference(P>0.05);the blood oxygen saturation in 2 groups after treatment increased,and APC combined with cyclocryotherapy group was higher than that in APC group;the ATS shortness of breath scores in 2 groups after treatment decreased,and APC combined with cyclocryotherapy group was lower than that in APC group(P<0.05).Compared with before treatment,the forced vital capacity(FVC),forced expiratory volume in 1 second(FEV1)of patients in 2 groups after treatment increased,and APC combined with cyclocryotherapy group was higher than that in APC group(P<0.05).Compared with before treatment,the serum PCT,hs-CRP contents and WBC,NEUT levels in 2 groups after treatment decreased significantly,and APC combined with cyclocryotherapy group was lower than those in APC group(P<0.05);the occurrence rates of bleeding,hypoxemia in APC combined with cyclocryotherapy group were lower than those in APC group(P<0.05).Conclusion APC combined with cyclocryotherapy could ease the clinical symptoms of patients with CAO combined with lung infection,reduce the serum PCT,hs-CRP contents and WBC,NEUT levels,inhibit the body’s inflammatory response,and restore the lung function;the clinical effect was better than APC therapy alone,and which had a good security.
作者
杨国兴
曹春强
纪宏丽
YANG Guo⁃xing;CAO Chun⁃qiang;JI Hong⁃li(Department of Respiratory Medicine,Liaoyang Central Hospital,Liaoyang,Liaoning 111000,China)
出处
《热带医学杂志》
CAS
2022年第1期78-81,共4页
Journal of Tropical Medicine
基金
辽宁省自然科学基金(2013041371)
关键词
中央气道狭窄
肺部感染
氩等离子体凝固
冷冻疗法
Central airway stenosis
Lung infection
Argon plasma coagulation
Cyclocryotherapy
