摘要
目的比较不同剂量舒芬太尼对小儿心脏手术麻醉应激反应和血流动力学的影响。方法选取梧州市红十字会医院2010年10月—2018年10月收治的小儿心脏病手术患儿32例,根据舒芬太尼麻醉剂量的不同分为低剂量组和高剂量组,各16例。低剂量组以2μg/kg剂量的舒芬太尼麻醉,高剂量组以10μg/kg剂量的舒芬太尼麻醉。比较两组麻醉诱导前(T1)、麻醉诱导后(T2)、气管插管后(T3)、切皮劈胸骨后(T4)和阻断开放后(T5)应激反应指标〔去甲肾上腺素(NE)、肾上腺素(E)浓度〕和血流动力学指标〔平均动脉压(MAP)、心率(HR)、收缩压(SBP)、舒张压(DBP)〕。结果T1、T2、T3、T4、T5时,高剂量组NE、E浓度低于低剂量组(P<0.01)。T1、T2、T3、T4、T5时,高剂量组MAP、HR、SBP、DBP高于低剂量组(P<0.01)。结论高剂量(10μg/kg)舒芬太尼在小儿心脏手术麻醉中可取得较好的麻醉效果,可在不影响血流动力学基础上,更好地降低手术麻醉应激反应,保证手术顺利进行。
Objective To compare the effects of different doses of sufentanil on anesthesia stress response and hemodynamics in pediatric cardiac surgery.Methods A total of 32 cases of children with heart disease were selected from October 2010 to October 2018 in Wu Zhou Red Cross Hospital,which were divided into low dose group and high dose group according to the amount of sufentanil.The low dose group was anesthetized with 2μg/kg sufentanil,while the high dose group was anesthetized with 10μg/kg sufentanil.Before anesthesia induction(T1),after anesthesia induction(T2),after tracheal intubation(T3),after skin incision and sternotomy(T4)and after block and opening(T5),the indexes of stress response(NE,E)and hemodynamics(MAP,HR,SBP,DBP)were compared between the two groups.Results At T1,T2,T3,T4 and T5,the NE and E concentrations in the high dose group were lower than the low dose group(P<0.01).At T1,T2,T3,T4 and T5,MAP,HR,SBP and DBP of the high dose group were higher than the low dose group(P<0.01).Conclusion High dose(10μg/kg)sufentanil can achieve better anesthesia effect in pediatric cardiac surgery anesthesia,it can better reduce the stress response of anesthesia without affecting hemodynamics,and ensure the smooth operation.
作者
苏瑛
SU Ying(Department of Anesthesiology,Wu Zhou Red Cross Hospital,Wuzhou 543002,China)
出处
《临床合理用药杂志》
2020年第3期21-22,25,共3页
Chinese Journal of Clinical Rational Drug Use
