摘要
目的探讨急性心肌梗死(acute myocardial infarction,AMI)患者血清基质金属蛋白酶9(matrix metalloproteinase9,MMP9)水平测定及预后判断价值。方法选择医院行冠状动脉介入治疗的68例AMI患者为观察组,选择同期68例健康体检者为对照组,采用酶联免疫法检测血清MMP9水平。并根据ROC分析结果MMP9预测最佳工作点200.06μg/L,将观察组患者分为高MMP9组(n=47)和低MMP9组(n=21),每6个月监测一次不良心血管事件发生情况,共进行2年随访,对比两组不良心血管事件发生率。结果对照组血清MMP9水平为(130.93±45.07)μg/L,观察组为(252.39±82.20)μg/L,观察组明显高于对照组,差异有统计学意义(P<0.05)。Logistic回归分析结果显示MMP9是AMI的独立危险因素之一(OR=1.837,P<0.05),此时敏感度和特异度分别为0.750和0.941。高MMP9组术后6、12、18、24个月不良心血管事件发生率均高于低MMP9组,且术后18个月和24个月高MMP9组发生率明显高于低MMP9组,差异有统计学意义(P<0.05)。结论AMI患者血清MMP9为高表达状态,MMP9与AMI预后有一定关联。
Objective To investigate the expression of matrix metalloproteinase 9(MMP9)in the serum of patients with acute myocardial infarction and its prognostic value.Methods Sixty-eight patients with acute myocardial infarction treated with direct coronary intervention in our hospital were selected as the observation group while another 68 healthy volunteers served as the control group.The levels of MMP9 in both groups were detected by ELISA.The patients in the observation group were divided into two groups according to MMP9 levels,with 47 cases in the high MMP9 group and 21 cases in the low MMP9 group,and the incidence of adverse cardiovascular events during follow up was compared between the two groups.Results The serum MMP9 level was(130.93±45.07)μg/L in the control group,much higher than(252.39±82.20)μg/L in the observation group(P<0.05).Logistic regression analysis results showed that MMP9 was one of the independent risk factors for AMI(OR=1.837,P<0.05).ROC analysis results showed that the AUC for MMP9 to predict AMI was 0.901,the optimal operation point was 200.06μg/L,and the sensitivity and specificity were 0.750 and0.941 respectively.According to the optimal operation point,patients in the observation group were divided into the high MMP9 group(n=47)and the low MMP9 group(n=21).The rate of adverse cardiovascular events at 6 months,12 months,18 months and24 months after surgery was higher in the high MMP9 group than in the low MMP9 group,especially at 18 months and 24 months after surgery(P<0.05).Conclusions Serum MMP9 is highly expressed in patients with acute myocardial infarction,and MMP9 can be used as a prognostic indicator.
作者
汪鲁青
姜花
马训凯
WANG Luqing;JIANG Hua;MA Xunkai(Department of Cardiology,Qinghai Red Cross Hospital,Xining 810000,China)
出处
《武警医学》
CAS
2019年第11期941-944,共4页
Medical Journal of the Chinese People's Armed Police Force
关键词
急性心肌梗死
基质金属蛋白酶9
预后影响
acute myocardial infarction
matrix metalloproteinase 9
prognostic impact
