摘要
目的基于Meta分析探讨血府逐瘀制剂治疗气滞血瘀证原发性痛经的临床疗效。方法通过计算机检索PubMed、Embase、Cochrane Library、Web of science、中国知网(CNKI)、万方(Wan-Fang)、中国生物医学文献数据库(CBM)、维普(VIP)等数据库,筛选自数据库建立之年至2020年5月发表的血府逐瘀汤的各种制剂治疗原发性痛经的随机对照试验。采用Rev Man 5.3、Stata 16软件进行Meta分析。结果(1)与对照组比较,二分类数据分析结果显示OR=3.95,95%CI[2.63,5.91],P<0.00001,有序数据分析结果显示OR=2.36,95%CI[1.84,3.02],P<0.05,均表明血府逐瘀制剂治疗气滞血瘀证原发性痛经疗效优于对照组;(2)两组中医证候总积分方面,中西医结合治疗组疗效优于西药对照组,且具有统计学意义(MD=-3.81,95%CI[-4.30,-3.32],P<0.00001),而在VAS疼痛评分改善方面结果显示无统计学意义;(3)在不良反应发生率方面,血府逐瘀制剂明显少于非血府逐瘀制剂组(OR=0.35,95%CI[0.20,0.62],P=0.0003)。结论单用血府逐瘀制剂或联合西药治疗气滞血瘀证原发性痛经的疗效明显优于对照组。然而,由于现有随机对照试验的质量偏低,具有局限性,结论并不完全准确。为了证实血府逐瘀制剂治疗气滞血瘀证原发性痛经的有效性,需要高质量的随机对照试验。
Objective To systematically evaluate the effectiveness of Xuefu Zhuyu preparation in the treatment of primary dysmenorrhea with Qi stagnation and blood stasis.Methods The electronic databases PubMed,Embase,Cochrane Library,Web of science,CNKI,WanFang,CBM,VIP were searched.All randomized controlled trials on the treatment of primary dysmenorrhea with Xuefu Zhuyu preparation since the establishment of the database until May 2020 were screened,and relevant literatures were manually searched.Meta analysis was performed using RevMan 5.3 and Stata 16 software.Results(1)Compared with the control group,the results of binary data analysis showed that(OR=3.95,95%CI[2.63,5.91],P<0.00001),and the results of ordered data analysis showed that(OR=2.36,95%CI[1.84,3.02],P<0.05),the therapeutic effect of Xuefu Zhuyu preparation on primary dysmenorrhea of Qi stagnation and blood stasis syndrome was better than that of the control group;(2)In the total score of TCM Syndromes of the two groups,the effect of the combined treatment group of traditional Chinese and Western medicine was better than that of the control group of Western medicine,and it was statistically significant(MD=-3.81,95%CI[-4.30,-3.32],P<0.00001),and there was no statistical significance in the improvement of VAS score;(3)In the incidence of adverse reactions,there were fewer adverse events in Xuefu Zhuyu preparation group compared with non Xuefu Zhuyu preparation group,and the results were statistically different[OR=0.35,95%CI(0.20,0.62),P<0.0003].Conclusion The curative effect of Xuefu Zhuyu preparation alone or combined with western medicine in the treatment of primary dysmenorrhea with Qi stagnation and blood stasis was significantly better than that of the control group.However,due to the low quality and limitations of the existing randomized controlled trials,the conclusions are not completely accurate.In order to confirm the effectiveness of Xuefu Zhuyu preparation in the treatment of primary dysmenorrhea with Qi stagnation and blood stasis,a high-quality randomized controlled trial is needed.
作者
柴美伶
王昕
CHAI Meiling;WANG Xin(Liaoning University of Traditional Chinese Medicine,Shenyang 110847,Liaoning,China;Affiliated Hospital of Liaoning University of Traditional Chinese Medicine,Shenyang 110032,Liaoning,China)
出处
《辽宁中医药大学学报》
CAS
2021年第11期132-137,共6页
Journal of Liaoning University of Traditional Chinese Medicine
基金
国家重点研发计划(2018YFC1707407)
中医药行业科研专项基金项目(201407001-7)
国家中医药管理局中医临床研究基地业务建设科研专项(JDZΧ2015064)
辽宁省中医药临床学(专)科能力建设资金资助项目(2018-125)
关键词
原发性痛经
血府逐瘀制剂
随机对照试验
气滞血瘀证
META分析
primary dysmenorrhea
Xuefu Zhuyu preparation
randomized controlled trials
Qi stagnation and blood stasis syndrome
Meta analysis
