摘要
目的探讨治疗痉挛型脑瘫有效中药的用药规律。方法检索中国知网、万方、维普、Pubmed、Web of science、Co-chrane library数据库中药治疗痉挛型脑瘫的文献,采用EXCEL表格分析中医证候,药物的服用方法,药物的频次、四气五味及归经,观察的指标;SPSS Modeler18.0软件进行组方规律分析、SPSS Statistics 24进行药物的因子分析和聚类分析探讨痉挛型脑瘫的药物运用规律。结果痉挛型脑瘫虚证为肝脾肾、气血虚,实证为肝风、瘀血、气滞;用药频数前4位:伸筋草、当归、牛膝、红花,用药性温,味为甘、辛、苦,归肝、肾、脾经,补虚药、祛风湿药最多。关联分析中透骨草-木瓜、鸡血藤、牛膝组合支持度、置信度最高。核心用药透骨草、牛膝、伸筋草、鸡血藤。提取6个公因子。聚类分析得出当归、赤芍、杜仲、木瓜、川芎、甘草、黄芪;红花、白芍、鸡血藤、伸筋草、透骨草、牛膝、桂枝、丹参、桑枝、艾叶两个方子。中药主要以外用熏蒸为主,主要改善肌张力及运动功能。结论痉挛型脑瘫病机为肝脾肾气血虚兼肝风内动,气滞血瘀;治疗以补益肝肾、健脾胃,益气补血扶助正气,以祛风活血通络祛邪。
Objective To explore the rule of traditional Chinese medicine in the treatment of spastic cerebral palsy.Methods The literature of traditional Chinese medicine treatment of spastic cerebral palsy was retrieved from the databases of China HowNet,Wanfang,VIP,PubMed,web of science and Co-crane library.The syndrome of traditional Chinese medicine,the method of taking medicine,the frequency of medicine,the four Qi and five flavors,the meridian tropism and the indexes of observation were analyzed by Excel.SPSS modeler 18.0 software was used for the analysis of the rule of composition.SPSS statistics factor analysis and cluster analysis were carried out to explore the drug use law of spastic cerebral palsy.Results The deficiency syndrome of spastic cerebral palsy was deficiency of liver,spleen and kidney,Qi and blood,and the excess syndrome was liver wind,blood stasis and Qi stagnation.The top 4 drugs were Shenjincao(Lycopodii Herba),Danggui(Angelicae Sinensis Radix),Niuxi(Achyranthis Bidentatae Radix),Honghua(Carthami Flos),which were mild in nature,sweet,pungent and bitter in taste.They were mainly used for liver,kidney and spleen meridian,and the most drugs were for tonifying deficiency and removing wind and dampness.In the correlation analysis,the combination of Tougucao(Speranskiae Tuberculatae Herba)-Mugua(Chaenomelis Fructus),Jixueteng(Spatholobi Caulis)and Niuxi(Achyranthis Bidentatae Radix)had the highest degree of support and confidence.The core drugs were Tougucao(Speranskiae Tuberculatae Herba),Niuxi(Achyranthis Bidentatae Radix),Shenjincao(Lycopodii Herba)and Jixueteng(Spatholobi Caulis).Six common factors were extracted.Cluster analysis showed that two prescriptions.One prescription included Danggui(Angelicae Sinensis Radix),Chishao(Paeoniae Radix Rubra),Duzhong(Eucommiae Cortex),Mugua(Chaenomelis Fructus),Chuanxiong(Chuanxiong Rhizoma),Gancao(Glycyrrhizae Radix Et Rhizoma),Huangqi(Astragali Radix)and the other prescription included Honghua(Carthami Flos),Baishao(PAeoniae Radix Alba),Jixueteng(Spatholobi Caulis),Shenjincao(Lycopodii Herba),Tougucao(Speranskiae Tuberculatae Herba),Niuxi(Achyranthis Bidentatae Radix),Guizhi(Cinnamomi Ramulus),Danshen(Salviae Miltiorrhizae Radix Et Rhizoma),Sangzhi(Mori Ramulus)and Aiye(Artemisiae Argyi Folium).Traditional Chinese medicine was mainly used for external fumigation,mainly to improve muscle tension and motor function.Conclusion In the treatment of spastic cerebral palsy,the treatment is tonifying liver and kidney,strengthening spleen and stomach,supplementing Qi and blood,strengthening Qi,promoting blood circulation and removing pathogenic factors.
作者
赵亚林
邓博文
张厚君
赵毅
徐林
穆晓红
ZHAO Yalin;DENG Bowen;ZHANG Houjun;ZHAO Yi;XU Lin;MU Xiaohong(Department of Orthopaedics,Dongzhimen Hospital,Beijing University of Traditional Chinese Medicine,Beijing 100029,China;Tieying Hospital of Fengtai District,Beijing 100079,China)
出处
《辽宁中医杂志》
CAS
2021年第9期6-10,221,共6页
Liaoning Journal of Traditional Chinese Medicine
基金
国家自然科学基金(8187152619)
关键词
痉挛型脑瘫
中药规律
关联规则
因子分析
聚类分析
spastic cerebral palsy
rule of traditional Chinese medicine
association rule
factor analysis
cluster analysis
