摘要
目的探讨百合固金汤中药联合莫西沙星对耐多药肺结核患者免疫指标、T细胞亚群及肺功能指标的影响。方法于2016年5月—2018年1月在医院进行治疗的耐多药肺结核患者中随机选取100例,按照随机数字标法将患者随机分为研究组与对照组两组,每组患者各50例。对照组患者给予莫西沙星口服,研究组患者在对照组的基础上给予百合固金汤中药水煎服。观察两组患者的临床疗效,免疫指标[免疫球蛋白G(IgG),免疫球蛋白A(IgA),免疫球蛋白M(IgM)],T细胞亚群指标[CD3+、CD4+、CD8+、CD4+/CD8+],肺功能指标[第一秒用力呼气容积(FEV1)、肺活量(FVC)与FEV1比值及每分钟最大通气量(MVV)],对两组患者治疗期间或治疗后发生的不良反应进行比较。结果两组患者经治疗后,研究组患者与对照组患者的总有效率分别为96.00%(48/50)、82.00%(41/50),对照组明显低于对照组(P<0.05)。治疗后,两组患者的IgG、IgA、IgM水平较治疗前均明显升高,且研究组上述免疫指标水平较对照组明显升高(P<0.05)。与治疗前相比,治疗后。两组患者CD3+、CD4+、CD4+/CD8+水平均明显升高,CD8+水平均明显降低,且研究组各指标较对照组变化更明显(P<0.05)。经治疗后,两组患者的FEV1、MVV及FEV1/FVC等肺功能指标均明显升高,且研究组各肺功能指标升高更明显(P<0.05)。研究组不良反应发生率为6.00%(3/50),明显低于对照组的24.00%(12/50)(P<0.05)。结论百合固金汤中药联合莫西沙星治疗耐多药肺结核,能够明显提高耐多药肺结核患者的免疫功能,改善患者的肺功能,临床疗效明显,安全可靠。
Objective To investigate the effect of Baihe Gujin Decoction combined with moxifloxacin on immune index,T cell subsets and pulmonary function index of MDR-TB patients.Methods From May 2016 to January 2018,100 MDR-TB patients in our hospital were randomly selected.According to the random number standard method,the patients were randomly divided into two groups:the study group and the control group,with 50 patients in each group.The patients in the study group were treated with Baihe Gujin Decoction on the basis of the control group.The clinical effects of the two groups were observed.The immune indexes[immunoglobulin G(IgG),immunoglobulin A(IGA),immunoglobulin M(IgM),T cell subsets(CD3+,CD4+,CD8+,CD4+/CD8+),lung function indexes(FEV1)in the first second,ratio of FVC to FEV1 and MVV in the first minute]were observed.During or after treatment,the adverse reactions after treatment were compared.Results After treatment,the total effective rate of the study group and the control group was 96.00%(48/50),which was significantly lower than that(82.00%,41/50)of the control group(P<0.05).After treatment,the levels of IgG,IgA and IgM in the two groups were significantly higher than those before treatment,and the levels of the above immune indexes in the study group were significantly higher than those in the control group(P<0.05).Compared with those before treatment,the levels of CD3+,CD4+and CD4+/CD8+in the two groups were significantly higher,and the levels of CD8+were significantly lower,and the changes of each index in the study group were more significant than those in the control group after treatment(P<0.05).After treatment,the pulmonary function indexes(FEV1,MVV and FEV1/FVC)in the two groups were significantly higher than those in the study group(P<0.05).The incidence of adverse reactions in the study group was 6.00%(3/50),which was significantly lower than that in the control group(24.00%,12/50)(P<0.05).Conclusion Baihe Gujin Decoction combined with moxifloxacin in the treatment of MDR-TB can significantly improve the immune function and the pulmonary function of patients.The clinical effect is obvious.The treatment is safe and reliable.
作者
黄晴
HUANG Qing(Department of Tuberculosis,Wuhan Jinyintan Hospital,Wuhan 430040,Hubei,China)
出处
《辽宁中医杂志》
CAS
2020年第8期124-126,共3页
Liaoning Journal of Traditional Chinese Medicine
