摘要
目的:探讨糖皮质激素辅助阿奇霉素作用下对儿童肺炎支原体大叶性肺炎症状的缓解以及对患儿体内炎症因子的影响。方法:回顾性分析在2017年9月至2019年9月本院收治的200例大叶性肺炎患儿作为研究对象,按治疗方法的不同分为观察组和对照组,观察组109例,对照组91例,对照组在常规治疗的基础上给予阿奇霉素治疗,观察组在对照组的基础上加用糖皮质激素进行治疗。对比两组患儿的临床效果、临床症状相关指标以及治疗前后相关炎性因子水平。结果:治疗后观察组的总有效率明显高于对照组(97.25%vs80.22%,P<0.05);观察组的咳嗽症状消失时间、发热体征消失时间、肺部啰音消失时间、胸片阴影消失时间、住院时间明显低于对照组(P<0.05);治疗1周后观察组的CRP、ESR、PCT、TNF-α、1L-6、水平明显低于对照组(P<0.05)。结论:糖皮质激素联合阿奇霉素在治疗儿童肺炎支原体大叶性肺炎方面临床疗效显著,不仅能减轻患儿的炎症反应,且对患儿的早日康复有积极作用。
Objective:To investigate the effect of glucocorticoid-assisted azithromycin on the relief of mycoplasma pneumoniae lobular pneumonia in children and the effect of inflammatory factors in children.Methods:A retrospective analysis in September 2017 to October 2019 in our hospital treated 200 cases of children with lobar pneumonia as the research object,according to the divided into observation group and control group,treatment group 109 cases,control group 91 cases,control group on the basis of routine therapy for azithromycin treatment,the observation group on the basis of the control group treated with glucocorticoid.The clinical effect,clinical symptom and inflammatory factors before and after treatment were compared between the two groups.Results:The total effective rate of the observation group after treatment was 97.25%higher than that of the control group(80.22%),the difference was highly significant(P<0.01).In the observation group,the time of disappearance of cough,the time of regression of fever,the time of disappearance of lung rhombus,the time of regression of chest radiogram shadow,and the length of hospitalization were lower than that in the control group,with statistically significant differences(P<0.01).After 1 week of treatment,CRP,ESR,PCT,TNF-levels and 1 l-6 levels in the observation group were lower than those in the control group,with statistically significant differences(P<0.01).Conclusion:Glucocorticoid combined with azithromycin has a significant clinical effect in the treatment of mycoplasma pneumoniae lobar pneumonia in children.
作者
廖惠映
刘玲
李微
林敏仪
LIAO Hui⁃ying;LIU Ling;LI Wei;LIN Min⁃yi(Department of pediatrics,Third affiliated hospital of guangdong medical university,Foshan,Guangdong,528318)
出处
《岭南急诊医学杂志》
2020年第5期496-498,共3页
Lingnan Journal of Emergency Medicine
关键词
糖皮质激素
阿奇霉素
儿童肺炎支原体
大叶性肺炎
炎性因子
glucocorticoid
azithromycin
mycoplasma pneumoniae in children
lobar pneumonia
inflammatory cytokines
