摘要
目的评价心房颤动(AF)患者sST2、高敏C反应蛋白(hs-CRP)水平与心脏结构的关系。方法选择在我院确诊AF患者64例,持续性AF组31例,阵发性AF组33例,同期健康体检者30例为对照组。行心脏超声学检查,并采用酶联免疫吸附法检测sST2、hs-CRP水平,分析sST2、hs-CRP和心脏超声学指标的关系。结果3组患者在左房内径(LAD)、hs-CRP和sST2水平上有明显差异(p<0.05)。Spearman相关分析显示AF患者年龄、LAD、hs-CRP与sST2水平呈正相关(r=0.188、0.454、0.357,p<0.05)。多元线性回归分析显示LAD和hs-CRP是影响AF患者sST2水平的因素。Logistic回归分析显示,LAD、hs-CRP和sST2水平是影响AF发生的危险因素。结论sST2和炎症参与AF患者左房重构,和AF发生相关。
Objective To evaluate association between serum level of sST2,high-sensitivity C-reactive protein(hs-CRP)and cardiac structure in patients with atrial fibrillation(Af).Methods 64 patients with Af were divided into persistent Af group(n=31)and paroxysmal Af group(n=33),and 30 patients without Af were included as control group.Detailed informations were recorded including the basic characteristics,the levels of plasma sST2,hs-CRP and transthoracic echocardiography indices.Results There were significant differences in plasma level of sST2,hs-CRP and Left atrial diameter(LAD)between 3 groups.Spearman correlation analysis showed that age,LAD and hs-CRP were positively correlated with sST2 level in Af patients(r=0.188,0.454,0.357,p<0.05).Multivariate linear regression analysis showed that LAD and hs-CRP were the factors affecting the level of sST2 in Af patients.Logistic regression analysis presented that LAD,hs-CRP and sST2 levels were risk factors for Af.Conclusions sST2 and inflammation are involved in left atrial remodeling in Af patients,and are associated with the occurrence of Af.
作者
杨树涵
陈红伟
刘艳宾
邢永生
Yang shuhan;Chen hongwei;Liu yanbin;Xing yongsheng(Xinxiang Central Hospital,Xinxiang,Henan,453000,China)
出处
《临床心电学杂志》
2020年第2期123-126,共4页
Journal of Clinical Electrocardiology
关键词
心房颤动
sST2
高敏C反应蛋白
左房内径
Atrial fibrillation
Soluble ST2
High-sensitivity C-reactive protein
Left atrial diameter
