摘要
二氧化钛(Ti O2)常作为食品添加剂用于糖果、巧克力、口香糖、饮料等食品。研究发现,Ti O2含有大量纳米级颗粒组分,含量可高达36%以上。鉴于纳米颗粒具有小尺寸、高表面活性等特殊理化性质,食品中纳米Ti O2对生物体可能具有与大颗粒Ti O2不同的健康影响。已证实,纳米Ti O2摄入后被胃肠道吸收并蓄积在肝脏、肾脏、脾脏等组织中,胃肠道作为纳米Ti O2摄入后的首要接触器官,更易受影响。本文总结当前食品中纳米Ti O2含量,提示人群在日常生活中能够通过各种食物接触到纳米Ti O2;了解不同年龄段人群Ti O2暴露水平,并进一步关注纳米Ti O2经口摄入后对胃肠道及常见疾病(胃溃疡、胃癌、肠炎、肠癌)等的影响;揭示纳米Ti O2胃肠道毒性作用,期望借此增加人们对食品中纳米Ti O2的了解,为指导纳米Ti O2在食品科学领域的安全有效应用提供参考依据。
Titanium dioxide(TiO2)is used in food like candy,chocolate,gum,and beverage as food additives.According to published research findings,the proportion of nanoparticles in food addictive TiO2 could be up to 36%.Because of the special physicochemical property of nanoparticles like small size and high surface activity,the influence of food-grade TiO2 nanoparticles on health may be different from that of larger-scale particles.TiO2 nanoparticles have been confirmed to be absorbed by the gastrointestinal tract and accumulate in organ tissues such as liver,kidney,and spleen after ingestion.The gastrointestinal tract is the primary contact organ after oral intake of TiO2 nanoparticles and is more susceptible than other organs.This article summarized the contents of TiO2 nanoparticles in food,suggesting human are exposed to TiO2 nanoparticles in daily life;summarized exposure levels in different age groups,further focused on the effects on gastrointestinal tract and diseases(such as gastric ulcer,gastric cancer,enteritis,and intestinal cancer)after ingestion of TiO2 nanoparticles;and revealed its toxic effects on gastrointestinal tract,expecting to promote public awareness of TiO2 nanoparticles in food and to provide reference for the safe and effective using of TiO2 nanoparticles in food science.
作者
段淑敏
高琰钧
吕利枝
王云
DUAN Shu-min;GAO Yan-jun;LüLi-zhi;WANG Yun(Department of Occupational and Environmental Health Science,School of Public Health,Peking University,Beijing 100191,China)
出处
《环境与职业医学》
CAS
CSCD
北大核心
2020年第2期181-186,191,共7页
Journal of Environmental and Occupational Medicine
基金
北京市自然科学基金(7172116)
国家自然科学基金(31971313,31400863).
关键词
纳米二氧化钛
食品添加剂
消化道
炎症
癌症
titanium dioxide nanoparticle
food addictive
digestive tract
inflammation
cancer
