摘要
目的探讨芪血通络片联合依达拉奉右莰醇治疗急性脑梗死的临床疗效及对患者氧化应激和炎性因子水平的影响。方法选择于2020年9至2021年2月就诊的急性脑梗死患者84例,随机分为观察组与对照组,各42例。2组入院均采取常规治疗。对照组给予依达拉奉右莰醇15 m L+生理盐水100 m L,iv gtt,bid;观察组在对照组基础上给予芪血通络片4片,po,tid。2组治疗疗程均为14 d。比较2组治疗前后美国国立研究院卒中量表(NIHSS)评分,Barthel指数,氧化应激[谷胱甘肽过氧化物酶(GSH-Px)、超氧化物歧化酶(SOD)和丙二醛(MDA)]水平,炎性因子[超敏C反应蛋白(hs-CRP)、肿瘤坏死因子-α(TNF-α)和白介素-6(IL-6)]水平及治疗疗效。结果治疗后,观察组NIHSS评分低于对照组,而Barthel指数高于对照组(P<0.05);血清GSHPx和SOD水平高于对照组,而MDA水平低于对照组(P<0.05);血清hs-CRP、TNF-α和IL-6水平均低于对照组(P<0.05)。2组总有效率比较,组间差异无统计学意义(P>0.05)。结论芪血通络片联合依达拉奉右莰醇对急性脑梗死患者疗效良好,可调节氧化应激水平及减轻炎性反应。
AIM To investigate the clinical effect of Qixuetongluo tablets combined with edaravone dexborneol on acute cerebral infarction and influence on oxidative stress and inflammatory factors in patients.METHODS A total of 84 patients with acute cerebral infarction treated in our hospital from September 2020 to February 2021 were randomly divided into observation group and control group,with 42 patients in each group.Two groups received routine treatment.The control group was given edaravone dextromethor 15 m L+normal saline 100 m L,iv gtt,bid.On the basis of the treatment of the control group,the observation group was given Qixuetongluo tablet 4 tablets,po,tid.The treatment course of both groups was 14 d.The NIHSS score,Barthel index,oxidative stress[glutathione peroxidase(GSH-Px),superoxide dismutase(SOD)and malondialdehyde(MDA)]and inflammatory factors[high sensitivity C-reactive protein(hs-CRP),tumor necrosis factor-α(TNF-α)and interleukin-6(IL-6)]levels and curative effects were compared between 2 groups before and 14 d after treatment.RESULTS After treatment,NIHSS score in the observation group was lower than that in the control group,while Barthel index was higher than that in the control group(P<0.05).The levels of serum GSH-Px and SOD in the observation group were higher than those in the control group,while the levels of MDA were lower than these in the control group(P<0.05).Serum hs-CRP,TNF-αand IL-6 levels in the observation group were lower than those in the control group(P<0.05).There was no significant difference between 2 groups(P>0.05).CONCLUSION Qixuetongluo tablets combined with edaravone dexborneol have good curative effect on patients with acute cerebral infarction,and can regulate the levels of oxidative stress and reduce inflammatory response.
作者
李晓彤
吕祥兄
LI Xiaotong;LYU Xiangxiong(Department of Neurology,Xiaoshan Hospital Affiliated to Hangzhou Normal University,Hangzhou 311200,China)
出处
《中国临床药学杂志》
CAS
2022年第3期206-209,共4页
Chinese Journal of Clinical Pharmacy
关键词
芪血通络片
依达拉奉右莰醇
急性脑梗死
疗效
氧化应激
炎性因子
Qixue tongluo tablet
edaravone dexborneol
acute cerebral infarction
curative effect
oxidative stress
inflammatory factor
