摘要
报告1例同时具有硬皮病样和皮肤异色病样皮损的慢性移植物抗宿主病。患者男,27岁。异基因造血干细胞移植3余年后,全身多发斑片3年,颈部及肩部皮肤硬化伴活动受限1年。皮肤科检查:项部、双上肢、肘窝及背部弥漫红斑伴苔藓样变,可见毛细血管扩张、色素沉着和色素脱失,呈皮肤异色病样表现。项部可见褐色斑块和结节,触之质硬,与正常皮肤界限不清,伴皮肤硬化、颈部活动受限及颈椎后伸障碍,呈前倾强迫体位,双肩关节外展、上举、前屈及后伸等活动受限。诊断:慢性移植物抗宿主病。
A case of chronic graft-versus-host disease manifested as both scleroderma and poikiloderma is reported.A 27-year-old male presented with general papules for three years and tightness in his neck and shoulder for one year.He was diagnosed with acute myeloid leukemia and received transplantation more than three years ago.Physical examination showed wide-spread,welldelimited,red macules with telangiectasis,hyperpigmentation and depigmentation,all making it look like poikiloderma.Brown plaques and nodules appeared on the back of neck with unclear boundary with localized sclerosis.He also developed activity limitation presented with compulsive forward flexion of the neck,difficulty in the movements of his bilateral shoulder,such as flexion,extension,abduction and lifting.The diagnosis of chronic graft-versus-host disease manifested as both scleroderma and poikiloderma was made.
作者
胡宇晴
张建中
HU Yu-qing;ZHANG Jian-zhong(Department of Dermatology,Peking University People’s Hospital,Beijing 100044,China)
出处
《临床皮肤科杂志》
CAS
CSCD
北大核心
2020年第2期95-97,共3页
Journal of Clinical Dermatology
