摘要
目的评估动态对比增强磁共振成像(DCE-MRI)的定量参数直方图对术前子宫内膜癌肿瘤分化程度的评估价值。方法搜集2016年1月至2019年2月于南通大学附属医院术前行DCE-MRI检查的子宫内膜癌患者70例。根据病理结果,患者分别被分为高/低级别组(47/23例)。通过后处理软件测量容积转移常数(Ktrans)、转运速率常数(Kep)、血管外细胞外容积分数(Ve)的直方图参数,包括均值、偏度、峰度和第10、25、50、75和90百分位数。对于不同组间的直方图参数进行独立样本t检验分析(正态分布)或Mann-Whitney U检验(偏态分布)。采用受试者工作特征(ROC)曲线分析来评价不同参数的诊断效能。结果DCE-MRI直方图参数中共17个指标在高/低级别子宫内膜癌患者中具有显著差异(P<0.05),其中Ktrans第50百分位数在区分高/低级别子宫内膜癌具有最高的诊断效能,以0.671为截断值,AUC为0.914,灵敏度和特异度分别为94.12%和72.97%。结论DCE-MRI参数直方图可以有助于评估子宫内膜癌分化程度,其中Ktrans第50百分位数是最佳鉴别参数。
Objective To evaluate the diagnostic value of quantitative parameter histogram of preoperative dynamic enhanced magnetic resonance imaging(DCE-MRI)in endometrial carcinoma(EMC)tumor pathology grade.Methods Seventy patients with histology-proved endometrial carcinoma who received DCE-MRI scanning before operation from January 2016 to February 2019 in the Affiliated Hospital of Nantong University were chosen.Patients were divided into low-and high-grade groups based on pathological grading.Ktrans,Kepand Veof each patient’s DCE-MRI parameter map were obtained by post-processing software.The mean,skewness,kurtosis,and the 10,25,50,75,and 90 percentiles of the cumulative frequency distribution of each parameter were calculated.Independent sample t-test,receiver operating characteristic(ROC)curve analysis were used for statistical analysis.Results For different pathological grades,Significant differences were observed in 17 metrics of DCE histogram parameters(P<0.05).ROC curve analyses showed that Ktrans50th percentile had the highest diagnostic efficacy in differentiating EMC grades.The AUC,cut-off value,sensitivity,and specificity of the Ktrans50th percentile were 0.914,0.671,94.12%and 72.97%,respectively.Conclusion DCE-MRI parameter histogram can help to assess the degree of differentiation of endometrial cancer,and the 50th percentile of Ktransis the best distinguishing parameter.
作者
孙茜楠
蒋璟璇
胡晨瑞
刘蓓蒂
徐剑峰
赵金丽
吴献华
SUN Xinan;JIANG Jingxuan;HU Chenrui(Department of Radiology,Affiliated Hospital of Nantong University,Nantong 226001,P.R.China)
出处
《临床放射学杂志》
CSCD
北大核心
2020年第11期2276-2281,共6页
Journal of Clinical Radiology
基金
南通市社会民生科技计划项目(编号:MS12020045)
关键词
子宫内膜癌
磁共振动态对比增强成像
直方图分析
Endometrial carcinoma
Dynamic contrast-enhanced magnetic resonance imaging
histogram analysis
