摘要
血管老化是指血管结构和功能随增龄而发生的退行性改变,其影响多种疾病的发生、进展和预后。血管内皮细胞和血管平滑肌细胞是构成血管壁的主要细胞,是血管老化的重要细胞生物学基础。近年来,外泌体微小RNA(miRNA)与血管老化的关系成为研究热点。本综述将总结外泌体miRNA在血管内皮细胞和平滑肌细胞衰老过程中的作用,同时讨论外泌体miRNA在血管老化相关性疾病中的功能。
Vascular aging refers to the degenerative changes of vascular structure and function with aging,which affect the occurrence,progress and prognosis of various diseases.Vascular endothelial cells and vascular smooth muscle cells are the essential component of vessel wall,which are the important cellular biological basis of vascular aging.In recent years,the relationship between microRNA(miRNA)of exosomes and vascular aging has become a research hotspot.This review will summarize the role of exosomal miRNA in the aging process of vascular endothelial cells and smooth muscle cells,and discuss the function of exosomal miRNA in vascular aging related diseases.
作者
倪宇晴
刘幼硕
NI Yuqing;LIU Youshuo(Department of Geriatrics,Second Xiangya Hospital,Central South University,Changsha,Hunan 410011,China)
出处
《中国动脉硬化杂志》
CAS
2020年第2期163-168,共6页
Chinese Journal of Arteriosclerosis
基金
国家自然科学基金面上项目(81770833)
2019年中南大学研究生自主探索创新项目(2019zzts354).
