摘要
目的探究在冠心病心绞痛患者的治疗中,应用尼可地尔对患者左心室功能以及斑块稳定性的影响。方法选取2020年11月~2021年11月来本院进行治疗的冠心病心绞痛患者96例为研究对象,随机分为2组,每组48例。常规组采用常规治疗方式,实验组在常规治疗的基础上结合尼可地尔治疗,比较两组患者经过治疗后的左室射血分数(left ventricular ejection fraction,LVEF)、左室舒张末内径(left ventricular end diastolic diameter,LVEDD)、左室收缩末期内径(left ventricular end systolic diameter,LVESD)以及脂蛋白相关磷脂酶A2(lipoprotein related phospholipase A2,Lp-PLA2)水平。结果实验组患者经过治疗后LVEF、LVEDD、LVESD以及Lp-PLA2等各项指标明显优于常规组,差异有统计学意义(P<0.05);实验组患者临床治疗疗效优于常规组,差异有统计学意义(P<0.05);实验组患者SQA评分优于常规组,差异有统计学意义(P<0.05);两组患者治疗后均可缓解心绞痛情况,实验组患者心绞痛发作持续时间、发作次数更少,差异有统计学意义(P<0.05);实验组不良反应发生率与常规组的不良反应发生率相近,差异无统计学意义(P>0.05)。结论在冠心病心绞痛患者的临床治疗中,应用尼可地尔对改善患者的左心室功能以及斑块稳定性都具有重要临床价值,值得推广。
Objective To explore the efficacy of nicorandil on left ventricular function and plaque stability in patients with angina pectoris of coronary heart disease.Methods Ninety-six patients with angina pectoris of coronary heart disease treated in our hospital from November 2020 to November 2021 were randomly divided into routine group and experimental group,with 48 patients in each group.The patients in the routine group were treated with routine treatment,and the patients in the experimental group were treated with nicorandil on the basis of routine treatment.The left ventricular ejection fraction(LVEF),left ventricular end diastolic diameter(LVEDD),left ventricular end systolic diameter(LVESD)and lipoprotein related phospholipase A2(Lp-PLA2)levels were compared between the two groups after treatment.Results After treatment,LVEF,LVEDD,LVESD and Lp-PLA2 in the experimental group were significantly better than those in the routine group,with significant difference(P<0.05).The clinical therapeutic effect of the experimental group was better than that of the routine group,with significant difference(P<0.05);The SQA score of the experimental group was better than that of the routine group,and the difference was statistically significant(P<0.05);After treatment,both groups of patients relieved angina pectoris.The duration and frequency of angina pectoris attack in the experimental group were less than those in the routine group,and the difference was statistically significant(P<0.05);The incidence of adverse reactions in the experimental group was similar to that in the routine group,and the difference was not statistically significant(P>0.05).Conclusion In the clinical treatment of angina pectoris of coronary heart diease,the application of nicorandil has important clinical value in improving left ventricular function and plaque stability,and is worth promoting.
作者
王杨
王雨晨
王奇
李天开
WANG Yang;WANG Yu-chen;WANG Qi;LI Tian-kai(Laborunion,The First Affiliated Hospital of Harbin Medical University,Harbin 150001,China;Department of Cardiovascular Medicine,The First Affiliated Hospital of Harbin Medical University,Harbin 150001,China)
出处
《哈尔滨医科大学学报》
CAS
2023年第4期379-382,共4页
Journal of Harbin Medical University
关键词
冠心病心绞痛
尼可地尔
左心室功能
斑块稳定性
angina pectoris of coronary heart disease
nicorandil
left ventricular function
plaque stability
