摘要
目的:探讨红细胞分布宽度(RDW)作为低氧血症生物标志物的价值,并确定红细胞分布宽度鉴别新生儿新生儿持续性肺动脉高压(PPHN)的最佳临界点。方法:2019年1月~2019年12月,所有确诊为PPHN且入住新生儿重症监护室(NICU)的低氧血症足月儿作为病例组,出生后第2天或第3天因非溶血性黄疸足月儿入院接受光疗的健康足月新生儿作为对照组。采集出生时血样,检测RDW。采用多元逻辑回归模型分析PPHN与RDW的相关性。采用接收器工作特性(ROC)曲线分析法确定RDW对新生儿PPHN的最佳临界点。结果:PPHN组RDW高于对照组,PPHN显著预测因子为产妇潜在疾病和RDW。ROC曲线分析显示RDW预测PPHN的最佳临界点为17.9(敏感性为85.71%)。RDW曲线下面积为0.9197。结论:RDW是易于检测的标志物,可在超声心动图检查前预测新生儿重症监护室低氧血症患儿PPHN的发生风险。
Objective To evaluate red cell distribution width(RDW)as a biomarker of hypoxemia and determine the optimal cutoff point of RDW for identifying neonates with PPHN.Methods All PPHN diagnosed,NICU admitted term infants with hypoxemia after birth from January 2019 to December 2019 were enrolled as case control and healthy term infants with nonhemolytic jaundice who were admitted for phototherapy on the second or third day of birth were the control group.Blood samples were collected.Multiple logistic regression modeling was used to examine the association between PPHN and RDW.Receiver-operating characteristics(ROC)curve analysis was used to determine the optimal cutoff point of RDW for identifying neonates with PPHN.Results RDW was higher in the PPHN group compared with the control group.Significant predictors of PPHN were mother’s underlying disease and RDW.The optimal RDW cut point for prediction of PPHN by the ROC curve analysis was 17.9(sensitivity=85.71%).RDW’s area under the curve was 0.9197.Conclusion RDW may be a simple,valuable,accessible marker for predicting PPHN before performing echocardiography in hypoxemic NICU admitted neonates.
作者
韵雪雪
Yun Xue-xue(Department of Clinical Laboratory,Women and Children’s Hospital,School of Medicine,University of Electronic Science and Technology of China,Chengdu 610054,China)
出处
《湖南师范大学学报（医学版）》
2020年第5期67-69,共3页
Journal of Hunan Normal University(Medical Sciences)
关键词
新生儿持续性肺动脉高压
低氧血症
新生儿重症监护室
红细胞分布宽度
persistent pulmonary
hypertension of the newborn
hypoxemia
neonatal intensive care unit
red cell distribution width
