摘要
目的:探讨2型糖尿病(T2DM)患者心外膜脂肪(EAT)厚度、C肽(FCP)与周围血管病变的关系。方法:回顾性研究2018年6月1日~2019年10月1日合肥市第一人民医院80例2型糖尿病患者临床资料,根据相关影像学检测情况,将其分为血管正常组40例,血管异常组40例。通过测定低密度脂蛋白胆固醇(LDL-C)、糖化血红蛋白(HbAlc)、收缩压(SBP)、高密度脂蛋白胆固醇(HDL-C)、甘油三酯(TG)、总胆固醇(TC)、FCP以及EAT厚度,比较分析两组间EAT厚度、FCP的变化情况与周围血管病变之间的关系。结果:血管异常组年龄、SBP、TC、EAT厚度、LDL-C显著高于血管正常组;血管异常组HDL-c、HbA1c、FCP显著低于血管正常组,差异具有统计学意义;FCP水平与EAT厚度、HBAC、TG、LDL-C、FCP、TC呈显著负相关,FCP水平与HDL-C呈显著正相关;EAT厚度与HbA1c、TG、LDL-C、TC呈正相关,EAT厚度与FCP、HDL-C呈负相关;通过Logistic回归分析分析表明,年龄、LDL、HbAlc以及EAT厚度为周围血管病的独立危险因素,而HDL-C、FCP为周围血管病的保护性因素。结论:2型糖尿病患者EAT厚度、FCP水平与周围血管病变具有一定程度的相关性。
Objective To investigate the relationship between epicardial fat(EAT)thickness,C-peptide(FCP)and peripheral vascular disease in patients with type 2 diabetes mellitus(T2DM).Methods The clinical data of 80 patients with type 2 diabetes mellitus from the First Affiliated Hospital of Anhui Medical University from June 1,2018 to October 1,2019 were retrospectively analyzed.According to the relevant imaging findings,40 patients were divided into normal blood vessels.40 cases of vascular abnormalities.By measuring low density lipoprotein cholesterol(LDL-C),glycated hemoglobin(HbAlc),systolic blood pressure(SBP),high density lipoprotein cholesterol(HDL-C),triglyceride(TG),total cholesterol(TC),C Peptide and EAT thickness were compared to analyze the relationship between epicardial fat thickness,C-peptide changes and peripheral vascular lesions.Results The age,SBP,TC,EAT thickness and LDL-C of vascular abnormal group were significantly higher than those of normal blood vessel group.HDL-c,HbALC and FCP were significantly lower in vascular abnormal group than in normal blood vessel group.The difference was statistically significant;FCP level was significantly negatively correlated with HBAC,TG,LDL-C,FCP,TC,and FCP level was significantly positively correlated with HDL-C and EAT thickness;The thickness of EAT was positively correlated with HBAC,TG,LDL-C,FCP and TC,and the thickness of EAT was negatively correlated with HDL-C.Logistic regression analysis showed that age,LDL,HbAlc and EAT thickness was an independent risk factor for peripheral vascular disease,while HLDL and FCP were protective factors for peripheral vascular disease.Conclusion The epicardial fat thickness and C-peptide level in patients with type 2 diabetes have a certain correlation with peripheral vascular lesions.The detection of EAT thickness and C-peptide level can effectively predict the occurrence of peripheral vascular lesions.
作者
刘皆
吕芳
王国娟
胡国平
孙春萍
张强
司玮
马维青
Liu Jie;Lv Fang;Wang Guo-juan;Hu Guo-ping;Sun Chun-ping;Zhang Qiang;Si Wei;Ma Wei-qing(Department of Endocrinology,Hefei First People’s Hospital,Heifei 230001,China)
出处
《湖南师范大学学报（医学版）》
2020年第3期132-136,共5页
Journal of Hunan Normal University(Medical Sciences)
关键词
2型糖尿病
心外膜脂肪厚度
C肽水平
周围血管病变
type 2 diabetes
epicardial fat thickness
C-peptide level
peripheral vascular disease
