摘要
SPATA基因是一类与精子发生相关的基因.精子发生依赖于一系列相关基因的正常表达与调控,SPATA基因在这个过程中起着一定的作用.本文通过参考大量SPATA基因相关文献,从SPATA基因在细胞增殖、细胞凋亡中的作用以及SPATA基因对多种相关疾病产生的影响和发病机理等多个方面,综述了精子发生过程中该类基因功能的研究进展,对于今后研究精子发生过程中有关特异基因的表达和细胞增殖、凋亡机理提供新思路;为研究精子发生的调控机制提供参考途径和方法;对于了解精子发生过程中产生的各种相关疾病的病因具有重要指导意义.
SPATA gene is a kind of gene related to spermatogenesis,which plays an important role in the process of spermatogenesis.Spermatogenesis is a multi-stage process of cell differentiation,which depends on the normal expression and regulation of a series of related genes.In this paper,the authors reviewed the mechanism of SPATA gene in spermatogenesis by referring to a large number of related literatures,including the roles of SPATA genes in cell proliferation and apoptosis,the effects of SPATA genes on a variety of related diseases and the study on the pathogenesis.It provides new ideas for studying the expression of specific genes and the mechanism of cell proliferation and apoptosis during spermatogenesis in the future.This review also provides reference ways and methods for studying the regulation mechanism of spermatogenesis.It has great significance to understand the etiology of various related diseases during spermatogenesis.
作者
张英
翟晓娜
ZHANG Ying;ZHAI Xiaona(College of Life Science,Luoyang Normal University,Henan Luoyang471022,China)
出处
《河南大学学报（自然科学版）》
CAS
2020年第6期684-690,共7页
Journal of Henan University:Natural Science
基金
国家自然科学基金资助项目(31971524)
关键词
精子发生
SPATA基因
睾丸发育
细胞增殖
细胞凋亡
spermatogenesis
SPATA genes
testicular development
cell proliferation
cell apoptosis
