摘要
目的:分析慢性牙周炎患者血清炎性因子表达特点及其临床意义。方法:将天津医科大学第二医院2015年3月~2018年3月收治的91例慢性牙周炎患者纳入患者组,并选取同期60名健康体检者纳入对照组。检测两组受试者入组时血清炎性因子表达水平,包括白细胞介素(IL)-1β、IL-6、IL-8及肿瘤坏死因子-α(TNF-α),并比较不同病情慢性牙周炎患者治疗前后血清炎性因子水平变化。结果:患者组血清IL-1β、IL-6、IL-8、TNF-α表达水平均高于对照组,差异有统计学意义(P<0.05)。轻度组、中度组、重度组患者治疗后血清IL-1β、IL-6、IL-8、TNF-α均较治疗前降低,中度组治疗前后上述指标均高于轻度组,重度组治疗前后上述治疗均高于中度组,差异有统计学意义(P<0.05)。结论:血清炎性因子表达的上升伴随着慢性牙周炎的发生发展,重视炎性因子水平的调控是改善患者牙周状态的关键环节。
Objective:To analyze the expression characteristics of serum inflammatory factors in patients with chronic periodontitis and its clinical significance.Methods:A total of 91 patients with chronic periodontitis admitted to our hospital from March 2015 to March 2018 were enrolled in periodontitis group,and 60 healthy people were enrolled in the control group during the same period.The levels of serum inflammatory factors,including interleukin-1β(IL-1β),interleukin-6,interleukin-8,and tumor necrosis factor-α(TNF-α),were measured in all subjects involved.The changes of serum inflammatory factors in patients with different digrees of chronic periodontitis were compared before and after treatment.Results:The levels of serum IL-1β,IL-6,IL-8,and TNF-αin periodontitis group were higher than those in control group(all P<0.05).The serum levels of IL-1β,IL-6,IL-8,and TNF-αin mild group,moderate group,and severe group were lower than those before treatment.The above indexes in moderate group were higher than those in mild group before and after treatment,and those in severe group were higher than those in moderate group before and after treatment,with statistical significance(P<0.05).Conclusion:The increase of serum inflammatory factors is accompanied by the occurrence and development of chronic periodontitis.Regulation of inflammatory factors is important for controlling the periodontal status of patients.
作者
王梅蕊
闫永发
WANG Meirui;YAN Yongfa(Dept.of Stomatology,Second Hospital of Tianjin Medical University,Tianjin 300211,China)
出处
《武汉大学学报（医学版）》
CAS
2020年第6期1003-1006,共4页
Medical Journal of Wuhan University
基金
天津医科大学科学基金资助项目(编号:2008ky31)
