摘要
目的本研究通过Meta分析,评估微小RNA-21(miRNA-21)对于胰腺癌患者预后的影响。方法检索PubMed、Medline、Embase、Web of Science等数据库检索已公开发表的相关文献,纳入符合条件的研究,提取生存资料HR及95%置信区间等信息,采用STATA12.0软件进行Meta分析。结果共计21篇文章(22项研究)、1420例胰腺癌患者符合纳入标准。结果显示:miRNA-21的表达水平与患者的总体生存率(OS)、无病生存期(DFS)间存在统计学意义(HR=1.65,95%CI 1.37~1.93,P<0.001;HR=1.01,95%CI 1.44~2.59,P<0.001)。进一步的亚组分析显示,在不同种族、检测方法及检测标本中,miRNA-21对于患者预后同样具有预测价值。对于接受辅助治疗的患者,miRNA-21的表达上调与患者预后具有相关性(HR=2.01,95%CI 1.58~2.47,P<0.001)。MiRNA-21的表达上调与转移性淋巴结及低分化肿瘤具有统计学意义(OR=1.53,95%CI 1.06~2.20,P=0.023;OR=2.01,95%CI 1.36~2.98,P<0.001),而miRNA-21表达水平高低与性别、血管浸润、神经浸润等无显著意义(P>0.05)。结论胰腺癌患者中miRNA-21的表达上调预示着其总生存率、无病生存期的降低,miRNA-21是判断胰腺癌患者预后的良好指标。
Objective The aim of this study was to evaluate the prognostic value of miRNA-21 on outcomes of pancreatic cancer patients with meta-analysis.Method We searched the published literatures in Pubmed、Medline、Embase、Web of Science et.al,and the eligible studies was included.The hazard radios(HR)and 95%confidence interval were calculated.We used STATA 12.0 software to meta-analysis for statistical analysis.Results A total of 21 articles(22 studies),1420 patients with pancreatic cancer were included for this meta-analysis.The results shows that the overexpression of miRNA-21 was statistically significant in patients with poor overall survival(OS)and disease-free survival(DFS)(HR=1.65,95%CI1.37~1.93,P<0.001;HR=1.01,95%CI1.44~2.59,P<0.001).In the subgroup analysis,it indicates that miRNA-21 is still a valued predictor for patient’s outcomes in different races,technique and test specimens.For the patients received adjuvant therapy,the overexpression of miRNA-21 indicate poor outcomes(HR=2.01,95%CI1.58~2.47,P<0.001).The up-regulation of miRNA-21 expression is statistically significant in metastatic lymph nodes and poorly differentiated tumors(OR=1.53,95%CI 1.06~2.20,P=0.023;OR=2.01,95%CI 1.36~2.98,P<0.001).There are no significant difference in miRNA-21 expression level and gender、vascular invasion、nerve infiltration(P>0.05).Conclusions The overexpression of miRNA-21 in patients with pancreatic cancer indicates a reduction in overall survival and disease-free survival.And the miRNA-21 is a good predictor of prognosis in patients with pancreatic cancer.
作者
栗志磊
王梦宇
许业传
LI Zhi-lei;WANG Meng-yu;XU Yechuan(The First Affiliated of Anhui Medical University,Hefei 230022,China)
出处
《肝胆外科杂志》
2020年第4期308-314,320,共8页
Journal of Hepatobiliary Surgery
基金
安徽高校自然科学研究项目(KJ2015A137)
