摘要
Objective: To evaluate the treatment and prognostic value of 12-lead electrocardiogram in idiopathic pulmonary hypertension (IPAH). Methods: A total of 200 patients with initial diagnosis of IPAH were included to analyze the correlation between ECG variables and hemodynamics.Univariate and multivariate proportional hazards regression analysis (Cox regression analysis) were used to analyze the changes of ECG parameters and determine the ECG parameters related to IPAH patients. Results: Partial correlation analysis showed that the amplitude of R wave in V1 lead was correlated with mPAP(r=0.343, P<0.001), and the sum of the amplitude of R wave in V1 lead and S wave in V5 lead was correlated with mPAP(r=0.504, P<0.001). The amplitude of R wave in V1 lead was correlated with mortality (HR 3.154, P<0.001), and the sum of the amplitude of R wave in V1 lead and S wave in V5 lead was correlated with mortality (HR 5.056, P<0.001). After 3 months of treatment,ECG parameters and hemodynamic status were improved. Conclusion: The specific 12-lead ECG parameters can reflect the improvement of the treatment of patients with idiopathic pulmonary hypertension and help to evaluate the prognosis of patients with idiopathic pulmonary hypertension.
基金
This study was supported by Jiangsu Provincial Natural Science Foundation Project(BK20151355)
Jiangsu Provincial Traditional Chinese Medicine Bureau Project(LB09041)
Nanjing University of Chinese Medicine Project(NZYLCZX2015-01)
