摘要
目的探讨利拉鲁肽注射液联合达格列净在2型糖尿病患者中的临床疗效.方法选取2021年8月—2023年5月临沂市中医医院收治的84例2型糖尿病患者为研究对象,按随机数字表法将其分为对照组与观察组,每组42例.对照组采用达格列净治疗,观察组在对照组基础上加用利拉鲁肽注射液治疗.对比两组患者的临床疗效、血糖指标、胰岛功能及不良反应发生情况.结果观察组治疗总有效率高于对照组,差异有统计学意义(P<0.05).治疗后,两组糖化血红蛋白、空腹血糖、餐后2h血糖水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05).治疗后,两组胰岛β细胞功能、空腹胰岛素、餐后2h胰岛素水平均高于治疗前,且观察组高于对照组,差异有统计学意义(P<0.05).治疗后,两组胰岛素抵抗指数均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05).两组不良反应发生率对比,差异无统计学意义(P>0.05).结论采用利拉鲁肽注射液联合达格列净治疗2型糖尿病的临床效果确切,使患者血糖指标以及胰岛功能指标得到有效改善,且安全性较佳.
Objective To explore the clinical efficacy of liraglutide injection combined with dagelin in patients with type 2 diabetes.Methods 84 patients with type 2 diabetes treated in Linyi Hospital of Traditional Chinese Medicine from August 2021 to May 2023 were selected as the study objects,and were divided into a control group and an observation group according to random number table method,with 42 cases in each group.The control group was treated with dagliprazin,and the observation group was treated with liraglutide injection on the basis of the control group.The clinical efficacy,blood glucose index,islet function and the occurrence of adverse reactions were compared between the two groups.Results The total effective rate of the observation group was higher than that of the control group,and the difference was statistically significant(P<0.05).After treatment,the levels of HBA1c,fasting blood glucose and 2 h postprandial blood glucose in two groups were lower than before treatment,and the observation group were lower than the control group,the difference was statistically significant(P<0.05).After treatment,isletβcell function,fasting insulin and 2 h postprandial insulin levels in two groups were higher than before treatment,and observation group were higher than control group,the difference was statistically significant(P<0.05).After treatment,insulin resistance index in 2 groups was lower than before treatment,and observation group was lower than control group,the difference was statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion The clinical effect of Lilalutide injection combined with Daggligin in the treatment of type 2 diabetes is definite,which can effectively improve the blood glucose index and pancreatic islet function index of patients,and has better safety.
作者
崔帆
CUI Fan(Department of Endocrinology,Linyi Traditional Chinese Medicine Hospital,Linyi Shandong,276000,China)
出处
《反射疗法与康复医学》
2024年第3期87-89,97,共4页
Reflexology And Rehabilitation Medicine
关键词
2型糖尿病
利拉鲁肽注射液
达格列净
临床疗效
血糖指标
Type 2 diabetes
Liraglutide Injection
Dapagliflozin
Clinical efficacy
Blood glucose indicators
