摘要
目的探究胞二磷胆碱联合替格瑞洛片治疗老年脑梗死的效果及对患者血液流变学指标、神经功能的影响。方法选择2020年4月—2023年4月兰陵县中医医院收治的80例老年脑梗死患者为研究对象,随机分为观察组及对照组,每组40例。对照组采用替格瑞洛片治疗,观察组采用替格瑞洛片联合胞二磷胆碱治疗,均持续2周。比较两组患者的血液流变学指标、不良反应发生情况、临床疗效及神经功能。结果观察组的治疗总有效率为95.00%,高于对照组的77.50%,差异有统计学意义(P<0.05)。治疗后,观察组的美国国立卫生研究院脑卒中量表评分低于对照组,差异有统计学意义(P<0.05)。治疗后,观察组的血浆黏度、全血高切黏度及血低切黏度均低于对照组,组间差异有统计学意义(P<0.05)。两组的不良反应总发生率比较,差异无统计学意义(P>0.05)。结论老年脑梗死患者采用胞二磷胆碱联合替格瑞洛片治疗的效果显著,可恢复其神经功能,调节血液流变学指标,且安全性高。
Objective To investigate the effect of the citicoline diphosphate combined with tigrinolol tablets in the treatment of elderly cerebral infarction and its influence on hemorheological indicators and neurological function.Methods 80 elderly patients with cerebral infarction admitted to Lanling County Traditional Chinese Medicine Hospital from April 2020 to April 2023 were selected as the study objects and randomly divided into an observation group and a control group,with 40 cases in each group.The control group was treated with tigrinolol tablets,and the observation group was treated with tigrinolol tablets combined with citicoline diphosphate.Both groups were treated for 2 weeks.The hemorheology indexes,adverse reactions,clinical efficacy and neurological function of the two groups were compared.Results The total effective rate of the observation group was 95.00%,which was higher than 77.50%of the control group,the difference was statistically significant(P<0.05).After treatment,the National Institute of Health Stroke Scale score of the observation group was lower than that of the control group,and the difference was statistically significant(P<0.05).After treatment,the plasma viscosity,whole blood high tangential viscosity and blood low tangential viscosity of the observation group were lower than those of the control group,and the differences between the groups were statistically significant(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion Citicoline diphosphate combined with tigrinolol tablets is effective in the treatment of elderly patients with cerebral infarction,which can restore the neurological function,regulate the hemorheology indexes and has high safety.
作者
杨祥梅
YANG Xiangmei(Department of Brain Disease,Lanling County Traditional Chinese Medicine Hospital,Linyi Shandong,277700,China)
出处
《反射疗法与康复医学》
2023年第23期115-117,共3页
Reflexology And Rehabilitation Medicine
关键词
脑梗死
老年
胞二磷胆碱
替格瑞洛片
血液流变学
神经功能
Cerebral infarction
Old age
Citicoline diphosphate
Tigrinolol tablets
Hemorheology
Neurological function
