摘要
目的探究左乙拉西坦片结合丙戊酸钠缓释片对癫痫患者血清神经递质水平、癫痫发作情况的影响。方法选择2021年3月—2023年3月我院收治的68例癫痫患者为研究对象,按随机数字表法将其分为对照组和观察组,每组34例。两组患者均给予禁烟禁酒、健康饮食、规律作息等一般治疗,对照组在一般治疗基础上给予患者丙戊酸钠缓释片,观察组在对照组基础上给予患者左乙拉西坦片。对比两组患者血清神经递质水平、癫痫发作情况和不良反应发生情况。结果治疗后,观察组miR-134-5p相对表达量(1.53±0.46)、脑源性神经营养因子水平(17.43±3.22)ng/L均低于对照组的(2.02±0.64)、(22.82±3.16)ng/L,观察组多巴胺(9.94±2.53)ng/L和5-羟色胺水平(69.45±11.26)ng/L均高于对照组的(7.92±1.87)ng/L、(62.37±10.66)ng/L,组间差异有统计学意义(P<0.05)。治疗后,观察组癫痫发作次数(0.34±0.05)次/年少于对照组的(1.52±0.50)次/年,观察组发作持续时间(2.16±0.54)min/次低于对照组的(3.65±0.72)min/次,组间差异有统计学意义(P<0.05)。两组不良反应发生情况对比,组间差异无统计学意义(P>0.05)。结论左乙拉西坦片联合丙戊酸钠缓释片治疗癫痫患者,有助于癫痫发作情况的改善,还可调节血清神经递质水平,且安全性较高,值得推广。
Objective To investigate the effects of levetiracetam tablets combined with sodium valproate sustained-release tablets on serum neurotransmitter levels and seizure status in epilepsy patients.Methods Selecting 68 epilepsy patients admitted to our hospital from March 2021 to March 2023 were selected as the research subjects,divided into a control group and an observation group using a random number table method,with 34 cases in each group.Both groups of patients were given general treatments such as smoking and alcohol prohibition,healthy diet,and regular sleep patterns.The control group was given sodium valproate sustained-release tablets in addition to general treatment,while the observation group was given levetiracetam tablets in addition to the control group.Compare the serum neurotransmitter levels,seizure status,and incidence of adverse reactions between two groups of patients.Results After treatment,the relative expression level of mrR-134-5p in the observation group was(1.53±0.46),brain derived neurotrophic factor(BDNF)levels(17.43±3.22)ng/L,lower than the control group's(2.02±0.64)and(22.82±3.16)ng/L,respectively,observation group dopamine(DA)(9.94±2.53)ng/L and serotonin(5-HT)levels(69.45±11.26)ng/L,higher than the control group at(7.92±1.87)ng/L and(62.37±10.66)ng/L,respectively,the difference between groups is statistically significant(P<0.05).After treatment,the number of seizures in the observation group was(0.34±0.05)times/year,which was lower than(1.52±0.50)times/year in the control group,the duration of seizures in the observation group was(2.16±0.54)min per episode,which was lower than the control group's(3.65±0.72)min per episode,the difference between groups is statistically significant(P<0.05).Comparison of adverse reactions between two groups,there is no statistically significant difference between groups(P>0.05).Conclusion The combination of levetiracetam tablets and sodium valproate sustained-release tablets in the treatment of epilepsy patients can help improve the seizure situation,regulate serum neurotransmitter levels,improve patient cognitive function,and have high safety.It is worth promoting.
作者
高媛媛
GAO Yuanyuan(Department of Neurology,The First People's Hospital of Ningyang County,Tai'an Shandong,271400,China)
出处
《反射疗法与康复医学》
2023年第22期131-134,共4页
Reflexology And Rehabilitation Medicine
关键词
癫痫
左乙拉西坦片
丙戊酸钠缓释片
血清神经递质水平
癫痫发作情况
Epilepsy
Levetiracetam tablets
Sodium valproate sustained-release tablets
Serum neurotransmitter levels
Epilepsy situation
