摘要
目的分析恩格列净结合利拉鲁肽及二甲双胍在超重及肥胖2型糖尿病(T2DM)患者中的应用效果.方法选择2020年10月—2022年8月该院收治的110例超重及肥胖T2DM患者,按随机数字表法分为两组,各55例.对照组采用二甲双胍联合利拉鲁肽治疗,观察组在对照组基础上加服恩格列净治疗,均持续治疗12周.对比两组治疗前后临床指标、糖脂代谢、胰岛功能及不良反应.结果治疗前,两组腰围、体质量指数(BMI)、空腹血糖(FPG)、餐后2 h血糖(2 hPG)、总胆固醇(TC)、甘油三脂(TG)、空腹C肽、餐后2 hC肽水平对比,组间差异无统计学意义(P>0.05);治疗后,观察组腰围小于对照组,BMI、FPG、2 hPG、TG、TC、空腹C肽、餐后2 hC肽水平均低于对照组,组间差异有统计学意义(P<0.05).两组不良反应发生率相比,差异无统计学意义(P>0.05).结论在二甲双胍联合利拉鲁肽基础上应用恩格列净治疗超重及肥胖T2DM患者中的效果确切,能提高其糖脂代谢能力,改善胰岛功能,且有较高的安全性.
Objective To analyze the effect of engliazine combined with liraglutide and metformin in overweight and obese type 2 diabetes mellitus(T2DM)patients.Methods 110 overweight and obese T2DM patients admitted to the hospital from October 2020 to August 2022 were selected and divided into two groups according to random number table method,with 55 patients in each group.The control group was treated with metformin combined with liraglutide,and the observation group was treated with engliazine on the basis of the control group,both lasted for 12 weeks.The clinical indexes,glucose and lipid metabolism,islet function and adverse reactions were compared between the two groups before and after treatment.Results Before treatment,the waist circumference,body mass index(BMI),fasting plasma glucose(FPG),2 hour postprandial blood glucose(2 hPG),total cholesterol(TC),triglyceride(TG),fasting C-peptide,and triglyceride level at 2 h postmeal were not significantly differents between the groups(P>0.05);after treatment,the waist circumference of the observation group was lower than that of the control group,and the BMI,the levels of FPG,2 hPG,TG,TC,fasting C-peptide and postmeal 2 hC peptide were lower than those of the control group,with statistical significance differents between groups(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion On the basis of metformin combined with liraglutide,engligliazine has a definite effect in overweight and obese patients with T2DM,which can improve the ability of glucose and lipid metabolism,improve the function of islets,and has a high safety.
作者
周克
ZHOU Ke(Department of Endocrinology,Renhuai People's Hospital,Guizhou Province,Renhuai Guizhou,564500,China)
出处
《反射疗法与康复医学》
2023年第3期145-148,共4页
Reflexology And Rehabilitation Medicine
