摘要
目的探讨乙酰半胱氨酸联合布地奈德雾化吸入治疗老年肺部感染的效果.方法选择2020年6月—2022年6月本院收治的192例老年肺部感染患者为研究对象,按随机数字表法分为两组.对照组(n=96)采用布地奈德雾化吸入,观察组(n=96)采用乙酰半胱氨酸联合布地奈德雾化吸入,均持续治疗7d.对比两组患者的临床疗效、症状恢复时间、肺部感染情况、炎性因子及不良反应发生情况.结果观察组的治疗总有效率为96.88%,高于对照组的88.54%,差异有统计学意义(P<0.05).观察组的退热、止咳、气促消失及肺部啰音消失时间分别为(3.20±0.77)d、(4.85±1.02)d、(3.61±0.65)d、(4.26±1.02)d,均短于对照组的(4.42±0.85)d、(6.25±1.24)d、(4.25±0.82)d、(5.52±1.05)d,组间差异有统计学意义(P<0.05).观察组治疗后的肺部感染评分为(2.20±0.54)分,低于对照组的(3.43±0.78)分,差异有统计学意义(P<0.05).观察组治疗后的降钙素原、超敏C-反应蛋白水平分别为(0.50±0.10)ng/mL、(3.32±0.65)mg/L,均低于对照组的(0.94±0.20)ng/mL、(5.44±1.05)mg/L,组间差异有统计学意义(P<0.05).两组治疗过程中均未发生不良反应.结论采用乙酰半胱氨酸联合布地奈德雾化吸入治疗老年肺部感染的效果显著,能有效促进患者的症状缓解,减轻肺部感染与炎症反应,且具有较好的应用安全性.
Objective To investigate the effect of acetylcysteine combined with budesonide aerosol inhalation in the treatment of elderly patients with pulmonary infection.Methods 192 elderly patients with pulmonary infection admitted to the hospital from June 2020 to June 2022 were selected as the research objects and were divided into two groups according to random number table method.The control group(n=96)received budesonide aerosol inhalation,and the observation group(n=96)received acetylcysteine combined with budesonide aerosol inhalation,both lasted for 7 days.The clinical efficacy,symptom recovery time,pulmonary infection,inflammatory factors and the occurrence of adverse reactions were compared between the two groups.Results The total effective rate of the observation group was 96.88%,higher than 88.54%of the control group,the difference was statistically significant(P<0.05).The disappearance time of fever,cough,shortness of breath and lung rale in the observation group were(3.20±0.77)d,(4.85±1.02)d,(3.61±0.65)d,(4.26±1.02)d,respectively,which were shorter than(4.42±0.85)d,(6.25±1.24)d,(4.25±0.82)d and(5.52±1.05)d in the control group,and the differences between the groups were statistically significant(P<0.05).The clinical pulmonary infection score of the observation group after treatment was(2.20±0.54)points,lower than(3.43±0.78)points of the control group,and the difference was statistically significant(P<0.05).The levels of procalcitonin and hypersensitive C-reactive protein in the observation group after treatment were(0.50±0.10)ng/mL and(3.32±0.65)mg/L,respectively,which were lower than(0.94±0.20)ng/mL and(5.44±1.05)mg/L in the control group,and the differences between the groups were statistically significant(P<0.05).No adverse reactions occurred in the two groups during the treatment.Conclusion Acetylcysteine combined with budesonide aerosol inhalation is effective in the treatment of elderly patients with pulmonary infection,which can effectively promote the relief of symptoms,reduce pulmonary infection and inflammation,and has good application safety.
作者
王博
张苏明
孟雷
WANG Bo;ZHANG Suming;MENG Lei(Intensive Care Unit,Xuzhou Medical University Affiliated Hospital East Hospital,Xuzhou Jiangsu,221000,China)
出处
《反射疗法与康复医学》
2023年第7期121-123,150,共4页
Reflexology And Rehabilitation Medicine
关键词
老年肺部感染
乙酰半胱氨酸
布地奈德
临床疗效
炎性因子
Senile pulmonary infection
Acetylcysteine
Budesonide
Clinical efficacy
Inflammatory factor
