摘要
目的探究糖皮质激素联合羟氯喹治疗系统性红斑狼疮(SLE)皮疹的效果.方法选取2019年1月-2021年1月该院收治的136例SLE皮疹患者,按照治疗方案的不同分为观察组(n=68)与对照组(n=68).对照组采用糖皮质激素治疗,观察组在对照组基础上联合羟氯喹治疗.对比两组临床疗效,治疗前、治疗4周后实验室检查指标水平,治疗前、治疗4周后SLE症状和负性情绪.结果观察组治疗总有效率为94.12%,高于对照组的82.35%,差异有统计学意义(P<0.05).治疗4周后,观察组CRP、ESR均低于对照组,TGF-β、补体C3均高于对照组,组间差异有统计学意义(P<0.05).治疗4周后,观察组SLEDAI、DASS-21评分均低于对照组,组间差异有统计学意义(P<0.05).结论糖皮质激素联合羟氯喹治疗能够减轻SLE皮疹症状,降低患者炎性因子水平,且缓解不良情绪.
Objective To explore the effect of glucocorticoid combined with hydroxychloroquine in the treatment of systemic lupus erythematosus(SLE)rash.Methods 136 SLE rash patients admitted to our hospital from January 2019 to January 2021 were selected,and they were divided into an observation group(n=68)and a control group(n=68)according to the different treatment options.The control group was treated with glucocorticoid,and the observation group was treated with hydroxychloroquine on the basis of the control group.The clinical efficacy,the levels of laboratory test index level before treatment and after 4 weeks of treatment,and SLE symptoms and negative emotions before and after 4 weeks of treatment were compared between the two groups.Results The total effective rate of the observation group was 94.12%,which was higher than the 82.35%of the control group,and the difference between the groups was statistically significant(P<0.05).After 4 weeks of treatment,CRP and ESR in the observation group were lower than those in the control group,TGF-βand complement C,were higher than those in the control group,and the differences between the groups were statistically significant(P<0.05).After 4 weeks of treatment,the scores of SLEDAI and DASS-21 were lower than those of the control group,and the differences between the groups were statistically significant(P<0.05).Conclusion Glucocorticoid combined with hydroxychloroquine can alleviate the rash symptom of SLE,reduce the level of inflammatory factors,and relieve negative emotions.
作者
秦蕊
苗会娜
王玲
QIN Rui;MIAO Huina;WANG Ling(Department of Dermatology and Venereology,Beijing Armed Police Corps Hospital,Beijing,100027,China;Department of Outpatient Health Care,Beijing Armed Police Corps Hospital,Beijing,100027,China)
出处
《反射疗法与康复医学》
2022年第1期126-128,142,共4页
Reflexology And Rehabilitation Medicine
关键词
糖皮质激素
羟氯喹
系统性红斑狼疮
皮疹
Glucocorticoids
Hydroxychloroquine
Systemic lupus erythematosus
Rash
