摘要
目的 探讨重复经颅磁刺激(repeated transcranial magnetic stimulation,rTMS)联合草酸艾司西酞普兰在抑郁症患者中的应用价值.方法 选取该院2019年5月—2021年2月收治的76例抑郁症患者,按照随机数字表法分为两组,每组38例.对照组采用草酸艾司西酞普兰治疗,研究组采用rTMS联合草酸艾司西酞普兰治疗,两组均持续治疗8周.比较两组的认知功能、睡眠障碍、神经递质指标水平及抑郁程度.结果 比较两组治疗前的简易智能精神状态检查量表(mini-mental state examination,MMSE)评分、匹兹堡睡眠质量指数(Pittsburgh sleep quality index,PSQI)评分,组间差异无统计学意义(P>0.05);治疗后,研究组的MMSE评分为(27.14±2.19)分,高于对照组的(25.39±2.08)分,而PSQI评分为(9.30±1.51)分,低于对照组的(11.64±1.98)分,组间差异有统计学意义(P<0.05).治疗后,研究组的各项神经递质指标水平均高于对照组,组间差异有统计学意义(P<0.05).治疗后,研究组的总体抑郁程度轻于对照组,差异有统计学意义(P<0.05).结论 rTMS联合草酸艾司西酞普兰能够有效减轻抑郁症患者的抑郁程度,调节神经递质表达,改善患者认知功能及睡眠障碍,值得临床推广应用.
Objective To investigate the application value of repeated transcranial magnetic stimulation(rTMS)combined with escitalopram oxalate in depressed patients.Methods A total of 76 patients with depression admitted to the hospital from May 2019 to February 2021 were divided into two groups according to the random number table method,with 38 cases in each group.The control group was treated with escitalopram oxalate and the study group was treated with rTMS combined with escitalopram oxalate,and both groups continued treatment for 8 weeks.The cognitive function,sleep disturbance,neurotransmitter index levels and depression level of the two groups were compared.Results The mini-mental state examination(MMSE)scores and Pittsburgh sleep quality index(PSQI)scores were compared between the two groups before treatment,and there were no statistically significant differences(P>0.05);after treatment,the MMSE score of the study group was(27.14±2.19)points,which was higher than(25.39±2.08)points of the control group,while the PSQI score was(9.30±1.51)points,which was lower than(11.64±1.98)points of the control group,the differences between the groups were statistically significant(P<0.05).After treatment,the levels of various neurotransmitters in the study group were higher than those in the control group,and the differences between the groups were statistically significant(P<0.05).After treatment,the overall depression level of the study group was lighter than that of the control group,and the difference was statistically significant(P<0.05).Conclusion The rTMS combined with escitalopram oxalate can effectively reduce the degree of depression in patients with depression,regulate the expression of neurotransmitters,and improve the cognitive function and sleep disorders of patients.It is worthy of clinical application.
作者
陈辉
CHEN Hui(Department of Psychiatry,Anqiu Kangning Psychiatric Hospital,Weifang Shandong,262100,China)
出处
《反射疗法与康复医学》
2021年第14期71-73,84,共4页
Reflexology And Rehabilitation Medicine
关键词
抑郁症
重复经颅磁刺激
草酸艾司西酞普兰
认知功能
睡眠障碍
Depression
Repeated transcranial magnetic stimulation
Escitalopram oxalate
Cognitive function
Sleep disorders
