摘要
目的:探讨醋酸甲羟孕酮、头孢曲松钠与甲硝唑联合治疗子宫内膜炎对患者炎症反应指标的影响。方法:回顾性分析2016年1月—2018年3月我院收治的100例子宫内膜炎患者的临床资料,依据用药方案的不同,分为对照组[头孢曲松钠(0.5 g加入至500 mL5%葡萄糖注射液中静脉滴注,qd)+甲硝唑(25 mg加入至500 mL5%葡萄糖注射液中静脉滴注,qd),50例]与观察组[醋酸甲羟孕酮(2 mg,qd)+头孢曲松(0.5g,qd)钠+甲硝唑(25g,qd),50例],比较两组炎症反应[白介素(IL)-2、IL-4、IL-10、基质金属蛋白酶(MMP-9)]、临床症状缓解时间及安全性。结果:治疗2个周期后,观察组IL-2与IL-10水平高于对照组,IL-4与MMP-9水平低于对照组,差异有统计学意义(P <0.05);观察组下腹胀痛、下腹坠痛与阴道出血缓解时间均短于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:子宫内膜炎患者通过醋酸甲羟孕酮、头孢曲松钠与甲硝唑联合治疗,可有效缩短临床症状缓解时间,利于缓解炎症反应,且安全性较高。
Objective:To investigate the effect of medroxyprogesterone acetate,ceftriaxone sodium and metronidazole on the inflammatory response of patients with endometritis.Methods:The clinical data of 100 patients with endometritis admitted to our hospital from January 2016 to March 2018 were retrospectively analyzed.According to the different medication schemes,the patients were divided into a control group[ceftriaxone sodium(0.5 g drug was added to 500 mL5%glucose injection,qd)plus metronidazole(25 mg drug was added to 500 mL5%glucose injection,qd),50 cases]and an observation group[medroxyprogesterone acetate(2 mg,qd)plus ceftriaxone sodium(0.5g,qd)plus metronidazole(25g,qd),50 cases].Inflammatory response[interleukin(IL)-2,IL-4,IL-10,matrix metalloproteinase(MMP-9)],clinical symptoms’relief time and safety were compared between the two groups.Results:After 2 cycles of treatment,the levels of IL-2 and IL-10 in the observation group were higher than those in the control group,and the levels of IL-4 and MMP-9 were lower than those in the control group,with statistically significant differences(P<0.05).The relief time of lower abdominal distending pain,lower abdominal bearing-down pain and vaginal bleeding in the observation group was shorter than that in the control group,with statistically significant differences(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:Medroxyprogesterone acetate,ceftriaxone sodium and metronidazole can effectively shorten the relief time of clinical symptoms in patients with endometritis and help to alleviate inflammations,and have high safety.
作者
郑遂玲
Zheng Sui-ling(Department of Obstetrics and Gynecology,Zhengzhou Sixth People’s Hospital,Zhengzhou Henan 450052,China)
出处
《中国合理用药探索》
CAS
2019年第2期53-55,59,共4页
Chinese Journal of Rational Drug Use
关键词
子宫内膜炎
醋酸甲羟孕酮
头孢曲松钠
甲硝唑
炎症反应
Endometritis
Medroxyprogesterone Acetate
Ceftriaxone Sodium
Metronidazole
Inflammatory Response
